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- W1418314897 abstract "The Ca2+/calmodulin-dependent protein kinase II is a multisubstrate protein kinase that is activated by increases in intracellular Ca2+ concentration. The mammalian kinase CaMKII phosphorylates a wide variety of intracellular proteins including metabolic enzymes, transmitter synthesizing enzymes, ion channels, membrane receptor proteins, and transcription factors. Although the molecular weight of DmCaMKII has not been determined by analogy with the mammalian enzyme, it is thought to be a heteromultimer composed of several subunits, all of which are catalytic. At least four alternatively spliced catalytic subunits have been described. The smallest corresponds to the a subunit and the largest to the b and δ subunits of rat CaMKII. The four known subunits of DmCaMKII arise by alternative splicing of a single gene. Like rat CaMKII, each subunit contains an N-terminal kinase domain followed immediately by an autoinhibitory region containing the autophosphorylation site at T287. The inhibitory domain partially overlaps the calmodulin-binding domain. The variable sequences are found between residues 347 and 397. The autophosphorylation sites (T287, T306, and S315) are conserved between rat and Drosophila melanogaster." @default.
- W1418314897 created "2016-06-24" @default.
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- W1418314897 date "1995-01-01" @default.
- W1418314897 modified "2023-09-27" @default.
- W1418314897 title "DmCaMKII" @default.
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- W1418314897 doi "https://doi.org/10.1016/b978-012324719-3/50033-9" @default.
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