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- W141837179 abstract "Recent research has shown that microRNAs (miRNAs) are highly regulated during cardiac hypertrophy. Some miRNAs such as miR21, 195, and 208 promote hypertrophy, whereas other miRNAs such as miR1 and 133a inhibit hypertrophy. To date no comparison of sex dependent cardiac miRNAs has been described. Estrogen has been shown to play a protective role in left ventricular hypertrophy and heart failure in both humans and rodent models. To determine sex specific regulation of miRNAs during cardiac hypertrophy we compared levels of miRNAs in a surgical mouse model for cardiac hypertrophy. Male and female C57BL6 mice underwent surgery to band their aortas, transaortic constriction. Banding results in pressure overload, which leads to left ventricle hypertrophy. Five weeks post surgery hearts were weighed and total RNA was extracted. The female hearts exhibited a lesser degree of hypertrophy in response to pressure overload. Real-time PCR Analysis has revealed sex specific patterns of miRNA expression in left ventricular hypertrophy. An understanding of sex specific regulation of miRNAs in the heart could have a far-reaching impact on the diagnosis and treatment of heart disease in both women and men." @default.
- W141837179 created "2016-06-24" @default.
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- W141837179 date "2010-04-01" @default.
- W141837179 modified "2023-09-26" @default.
- W141837179 title "CHARACTERIZING SEX DIFFERENCES IN miRNA EXPRESSION IN LEFT VENTRICULAR HYPERTROPHY IN MICE" @default.
- W141837179 doi "https://doi.org/10.1096/fasebj.24.1_supplement.493.3" @default.
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