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- W1418425332 abstract "OBJECTIVE: To identify sensitive objective indices of balance impairment in minimally disabled patients with multiple sclerosis (MS). BACKGROUND: Balance impairment causes significant disability in patients with MS. Inertial sensors may provide more sensitive measures of balance impairment than current clinical measures and could direct early therapeutic interventions. DESIGN/METHODS: While wearing wireless inertial sensors, 20 subjects with MS - Expanded Disability Status Scale of less than 3 and a Timed Twenty-Five Foot Walk of 5 seconds or less - and 20 age- and sex-matched control subjects stood with eyes open and eyes closed. Forty-six outcome measures of postural sway were derived, then averaged by trial and condition, for each subject. Differences in each measure between the groups with and without MS were determined using Mann-Whitney U tests (Bonferroni-corrected p = 0.00054). A stepwise logistic regression model determined which measures of instrumented sway provide independent predictors of group status. RESULTS: In the eyes-open condition, 15 measures were significantly different between the groups with and without MS, and in the eyes-closed condition, 22 measures were significantly different. The regression model identified medio-lateral sway path length and medio-lateral range of sway acceleration amplitude, each in the eyes-open condition, as the only two significant independent predictors to differentiate subjects with MS from those without MS (model chi-squared = 34.55, p < 0.0001): accuracy = 87.5[percnt], positive likelihood ratio = 6 (2.09-17.21), negative likelihood ratio = 0.12 (0.03-0.44). CONCLUSIONS: Postural sway abnormalities in subjects with MS who are minimally disabled were detected using wireless inertial sensors and may signify a superior sensitivity in the identification of balance impairment prior to the development of clinically evident disability or impaired gait speed. Further study is needed to confirm the clinical significance and predictive value of these objectively identified balance impairments. Disclosure: Dr. Solomon has nothing to disclose. Dr. Jacobs has nothing to disclose. Dr. Lomond has nothing to disclose. Dr. Kasser has nothing to disclose. Dr. Henry has nothing to disclose." @default.
- W1418425332 created "2016-06-24" @default.
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- W1418425332 date "2015-04-06" @default.
- W1418425332 modified "2023-09-24" @default.
- W1418425332 title "Detection of Postural Sway Abnormalities by Wireless Inertial Sensors in Minimally Disabled Patients with Multiple Sclerosis (P5.189)" @default.
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