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- W1418508738 abstract "Cultured rat aortic smooth muscle cells (cultured rat aortic SMCs: 5×105) suspended in the upper compartment of a Boyden chamber migrated through the pores of the filters separating the two compartments in response to rat platelet-derived attractant (rat PDA) in the lower compartment. We have previously demonstrated that this enhanced migration is inhibited when the filter is coated with elastin purified from normal human aorta. However, cultured rat aortic SMCs again migrate well toward the rat PDA when the elastin-coated filter is treated prior to the migration assay with 15% human plasma LDL. Pretreatment of elastin-coated filters with 15% human plasma HDL fails to remove the inhibitory effect of elastin. Pretreatment of elastin-coated filters with rabbit-anti human aortic elastin antibody at protein concentrations of from 36μg/ml to 36mg/ml also removed the inhibitory effect of elastin, although to the lesser extent than the effect of LDL.These results suggest that the atherogenic effect of LDL might be due in part to an effect in vivo on the elastin, elastic fibers of the arterial wall." @default.
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- W1418508738 date "1992-01-01" @default.
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- W1418508738 title "LDL Eliminates the Inhibitory Effect of Human Aortic Elastin on Cultured Rat Aortic Smooth Muscle Cell Migration <i>In Vitro</i>" @default.
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- W1418508738 doi "https://doi.org/10.5551/jat1973.20.8-9_703" @default.
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