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- W141891387 abstract "For many years, medicinal chemistry has been largely the province of organic and natural products chemists, with the great majority of all chemotherapeutic agents being metal-free organic or biochemicals. Yet where metal complexes have been used, or the involvement of metals in the mechanism of action of organic compounds recognized, there is ample evidence of the enormous potential that metal complexes have in drug design. Considering cancer chemotherapy, there are several major examples in which metal complexes have been shown to have substantial anti-tumor activity or to be cytotoxic to tumor cells. As shown in Figure 1, bis(thiosemicarbazonato) copper(II) complexes, copper-bleomycin, cis-dichlorodiammine platinum (II) complexes, some rhodium(II) carboxylates, and recently, iron and copper complexes of α-N-heterocyclic formyl thiosemicar-bazones fall into this category.(1–5)" @default.
- W141891387 created "2016-06-24" @default.
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- W141891387 date "1978-01-01" @default.
- W141891387 modified "2023-09-27" @default.
- W141891387 title "Reaction of Copper Complexes with Ehrlich Cells" @default.
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- W141891387 doi "https://doi.org/10.1007/978-1-4684-0796-9_13" @default.
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