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- W141924144 abstract "BH4 is the cofactor for Phenylalanine hydroxylase, as well as tyrosine and tryptophan hydroxylases, which are the rate-limiting enzymes in catecholamine (CA) and Serotonin synthesis, respectively. CTP cyclohydrolase (CTP-CH) and sepiapterin reductase (SR) catalyze the initial and final steps in BH4 biosynthesis, respectively. Because no intermediates are detected, CTP-CH is thought to be the rate-limiting enzyme in nonprimate BH4 biosynthesis. In humans, the existence of neopterin in fluids suggests that other enzymes following CTP-CH may also play a regulatory role in BH4 biosynthesis." @default.
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- W141924144 date "1993-01-01" @default.
- W141924144 modified "2023-09-27" @default.
- W141924144 title "Co-Induction of Tetrahydrobiopterin (BH4) Levels and Tyrosine Hydroxylase Activity in Cultured PC12 Cells" @default.
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- W141924144 doi "https://doi.org/10.1007/978-1-4615-2960-6_45" @default.
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