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- W1419451010 abstract "Multiple sclerosis (MS) is known to be a chronic immune-mediated disease of the central nervous system characterized by lesions predominantly in white matter of the brain and spinal cord and by a chronic progression. It affects mainly young people and leads to their irreversible disability. This fact determines high social and economic significance of MS. A multifactorial nature of MS is suggested by the results of investigation, and vitamin D deficiency is presumed to be a possible risk factor. “Non-classical” effects of vitamin D, including its effect on the immune response, are widely studied in the recent years. This review is devoted to the analysis of clinical and experimental data about the association between vitamin D deficiency and MS. It also discusses the pathogenetic effect of vitamin D and analyzed the need and ways for correction of vitamin D deficiency in MS. In this publication we discuss the possible direction of further research in order to establish the optimal dosage and duration of vitamin D treatment in MS." @default.
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- W1419451010 date "2015-01-01" @default.
- W1419451010 modified "2023-09-27" @default.
- W1419451010 title "Multiple sclerosis and vitamin D status" @default.
- W1419451010 doi "https://doi.org/10.18705/1607-419x-2015-21-2-121-129" @default.
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