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- W1420359212 abstract "This chapter describes a compartmental model developed to examine sodium fluxes in isolated perfused proximal tubule segments of the rabbit. A four-step experimental protocol that can be applied to the compartmental analysis and provides a means for testing the applicability of the model to the proximal tubular epithelium is also described. There are several distinct advantages to the choice of the isolated perfused tubule as an experimental technique—for example, the technique can be applied to investigate other tubular segments including those not available to surface micropuncture. Also, as an in vitro preparation, the experimenter has excellent control over the luminal and bath compartments. In addition, the epithelium is isolated as a single cell layer and, therefore, closely approximates a three-compartment system. In presenting the model and experimental procedure in general terms it is expected that the concepts and methodology may have application to other transported species not only in the proximal tubule but also in other nephron segments." @default.
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- W1420359212 date "1980-01-01" @default.
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- W1420359212 title "Chapter 15 A Kinetic Model for Ion Fluxes in the Isolated Perfused Tubule" @default.
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- W1420359212 doi "https://doi.org/10.1016/s0070-2161(08)60283-x" @default.
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