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• W142074258 startingPage "119" @default.
• W142074258 abstract "A general principle of membrane transport which has been extensively investigated is that of the nonionic diffusion of dissociable solutes across membranes. This principle is particularly evident where no specific transport mechanism exists to accelerate their permeation. The pH of a solute-containing phase, by altering the concentration of undissociated solute available for diffusion across a membrane permeable only to the nonionised form, will alter the overall apparent rate of solute transfer. Another expression of this general principle is the pH partition hypothesis based on the central assumption that ionised forms of solutes do not permeate membranes easily, if at all, unless there is a specific transport mechanism in operation. Any pH differences across such a membrane will cause a partition of solute in a predictable manner depending on the pH of the phases and the pK a of the solute under investigation. This is well known to pharmacologists and has been experimentally substantiated on many occasions by drug elimination studies in the kidney (Milne et al. 1958; Beckett and Rowland 1964), with artificial membrane systems (Doluisio and Swintosky 1964; Samuelov et al. 1979) and in gastrointestinal membranes such as the gastric mucosa, the small bowel, colon and rectum (Shore et al. 1957; Schanker et al. 1957, 1958, Schanker 1959; Hogben et al. 1959). What is perhaps less generally realised is the fact that in the small bowel, especially in the jejunum, although the degree of ionisation and the extent of absorption parallel one another, the two parameters do not coincide." @default.
• W142074258 created "2016-06-24" @default.
• W142074258 creator A5013857482 @default.
• W142074258 date "1984-01-01" @default.
• W142074258 modified "2023-10-14" @default.
• W142074258 title "The Surface pH of the Intestinal Mucosa and its Significance in the Permeability of Organic Anions" @default.
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