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- W1421310 abstract "Publisher Summary This chapter describes the metabolism of pyruvate in animals. Pyruvate is metabolized by three major routes in animal tissues. It can be oxidized through the citrate cycle with concomitant synthesis of ATP. It can be metabolized to fatty acids, and it can also be converted into glucose. Pyruvate oxidized through the citrate cycle or incorporated into fatty acids is in general formed by glycolysis, and pyruvate dehydrogenase act in concert. It is found that when pyruvate is converted into glucose, glycolysis is a competing pathway, and pyruvate is derived from amino acids, or lactate. Enzymes involved in the initial reactions of pyruvate metabolism are mitochondrial. Therefore, mitochondrial transport of pyruvate is an obligatory reaction in each pathway. In some tissues mitochondrial metabolism of pyruvate is restricted to oxidation through the citrate cycle. Such tissues usually contain M-type pyruvate kinase, and pyruvate carboxylase activity is low." @default.
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- W1421310 date "1978-01-01" @default.
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- W1421310 title "METABOLISM OF PYRUVATE IN ANIMALS" @default.
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- W1421310 doi "https://doi.org/10.1016/b978-0-08-022623-1.50006-x" @default.
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