FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1421833322> ?p ?o ?g. }

• W1421833322 endingPage "98" @default.
• W1421833322 startingPage "684" @default.
• W1421833322 abstract "7-Hydroxymethyl-12-methylbenz[a]anthracene (7-HMBA) and 12-hydroxymethyl-7-methylbenz[a]anthracene (12-HMBA), carcinogenic major metabolites of 7,12-dimethylbenz[a]anthracene (DMBA) in untreated rat liver, showed high mutagenic activities toward Salmonella typhimurium TA 98 after preincubation with a sulfotransferase-PAPS system consisting of ATP, sodium sulfate, and a post-mitochondrial fraction (S-9) or a soluble supernatant fraction (S-105) from untreated rat liver. The 7- and 12-HMBAs themselves induced His+ mutation in TA 98 only slightly after preincubation with S-9 in the presence of an NADPH-generating system. Mutagenicity of DMBA toward TA 98 after preincubation with S-9 in the presence of the NADPH-generating system was remarkably enhanced by the addition of ATP and sodium sulfate. The active metabolites, 7-HMBA sulfate and 12-HMBA sulfate, were isolated from these preincubation systems and identified by comparison with the corresponding synthetic specimens. The sulfuric acid ester conjugates were potent mutagens toward TA 98 in the absence of rat liver subcellular fractions. The conjugates bound covalently at significant rates to calf-thymus DNA as well as to S-105 proteins at 37 degrees and pH 7.4 through the 7- or 12-methylene carbon with concomitant loss of their sulfate group. In the presence of S-105, glutathione inhibited the mutagenicity of the metabolically formed or exogenously added 7- and 12-HMBA sulfates. The non-mutagenic glutathione conjugates were isolated from the incubation mixtures and identified as S-(12-methylbenz[a]anthracen-7-yl)methylglutathione from 7-HMBA or its sulfate and S-(7-methylbenz[a]anthracen-12-yl)methylglutathione from 12-HMBA or its sulfate." @default.
• W1421833322 created "2016-06-24" @default.
• W1421833322 creator A5021151911 @default.
• W1421833322 creator A5035906872 @default.
• W1421833322 creator A5044547955 @default.
• W1421833322 creator A5066402317 @default.
• W1421833322 creator A5078608341 @default.
• W1421833322 date "1985-08-01" @default.
• W1421833322 modified "2023-09-25" @default.
• W1421833322 title "Sulfate esters of hydroxymethyl-methyl-benz[a]anthracenes as active metabolites of 7,12-dimethylbenz[a]anthracene." @default.
• W1421833322 cites W1554537892 @default.
• W1421833322 cites W1558063719 @default.
• W1421833322 cites W1572995407 @default.
• W1421833322 cites W1649900618 @default.
• W1421833322 cites W1775749144 @default.
• W1421833322 cites W1970607529 @default.
• W1421833322 cites W1973195696 @default.
• W1421833322 cites W1987549802 @default.
• W1421833322 cites W1996203696 @default.
• W1421833322 cites W1996507974 @default.
• W1421833322 cites W2001116094 @default.
• W1421833322 cites W2001529791 @default.
• W1421833322 cites W2008705536 @default.
• W1421833322 cites W2011768665 @default.
• W1421833322 cites W2016871310 @default.
• W1421833322 cites W2047285844 @default.
• W1421833322 cites W2048307591 @default.
• W1421833322 cites W2048754192 @default.
• W1421833322 cites W2052949624 @default.
• W1421833322 cites W2053166937 @default.
• W1421833322 cites W2053831151 @default.
• W1421833322 cites W2068680016 @default.
• W1421833322 cites W2068946850 @default.
• W1421833322 cites W2070904784 @default.
• W1421833322 cites W2098006877 @default.
• W1421833322 cites W2105891424 @default.
• W1421833322 cites W2108002436 @default.
• W1421833322 cites W2110057880 @default.
• W1421833322 cites W2124767862 @default.
• W1421833322 cites W2138993015 @default.
• W1421833322 cites W2167745074 @default.
• W1421833322 cites W2395198642 @default.
• W1421833322 cites W2416472161 @default.
• W1421833322 cites W2493873631 @default.
• W1421833322 cites W2502141709 @default.
• W1421833322 cites W2415007338 @default.
• W1421833322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3930446" @default.
• W1421833322 hasPublicationYear "1985" @default.
• W1421833322 type Work @default.
• W1421833322 sameAs 1421833322 @default.
• W1421833322 citedByCount "3" @default.
• W1421833322 crossrefType "journal-article" @default.
• W1421833322 hasAuthorship W1421833322A5021151911 @default.
• W1421833322 hasAuthorship W1421833322A5035906872 @default.
• W1421833322 hasAuthorship W1421833322A5044547955 @default.
• W1421833322 hasAuthorship W1421833322A5066402317 @default.
• W1421833322 hasAuthorship W1421833322A5078608341 @default.
• W1421833322 hasConcept C104317684 @default.
• W1421833322 hasConcept C114246631 @default.
• W1421833322 hasConcept C178790620 @default.
• W1421833322 hasConcept C181199279 @default.
• W1421833322 hasConcept C185592680 @default.
• W1421833322 hasConcept C2776260934 @default.
• W1421833322 hasConcept C2777477808 @default.
• W1421833322 hasConcept C2778343803 @default.
• W1421833322 hasConcept C2778938436 @default.
• W1421833322 hasConcept C2779563022 @default.
• W1421833322 hasConcept C2780591741 @default.
• W1421833322 hasConcept C538909803 @default.
• W1421833322 hasConcept C55493867 @default.
• W1421833322 hasConcept C555283112 @default.
• W1421833322 hasConcept C71240020 @default.
• W1421833322 hasConceptScore W1421833322C104317684 @default.
• W1421833322 hasConceptScore W1421833322C114246631 @default.
• W1421833322 hasConceptScore W1421833322C178790620 @default.
• W1421833322 hasConceptScore W1421833322C181199279 @default.
• W1421833322 hasConceptScore W1421833322C185592680 @default.
• W1421833322 hasConceptScore W1421833322C2776260934 @default.
• W1421833322 hasConceptScore W1421833322C2777477808 @default.
• W1421833322 hasConceptScore W1421833322C2778343803 @default.
• W1421833322 hasConceptScore W1421833322C2778938436 @default.
• W1421833322 hasConceptScore W1421833322C2779563022 @default.
• W1421833322 hasConceptScore W1421833322C2780591741 @default.
• W1421833322 hasConceptScore W1421833322C538909803 @default.
• W1421833322 hasConceptScore W1421833322C55493867 @default.
• W1421833322 hasConceptScore W1421833322C555283112 @default.
• W1421833322 hasConceptScore W1421833322C71240020 @default.
• W1421833322 hasIssue "8" @default.
• W1421833322 hasLocation W14218333221 @default.
• W1421833322 hasOpenAccess W1421833322 @default.
• W1421833322 hasPrimaryLocation W14218333221 @default.
• W1421833322 hasRelatedWork W1554537892 @default.
• W1421833322 hasRelatedWork W2001116094 @default.
• W1421833322 hasRelatedWork W2033587424 @default.
• W1421833322 hasRelatedWork W2040228769 @default.
• W1421833322 hasRelatedWork W2048761548 @default.
• W1421833322 hasRelatedWork W2092703933 @default.
• W1421833322 hasRelatedWork W2168444622 @default.

• next