Matches in SemOpenAlex for { <https://semopenalex.org/work/W1421933048> ?p ?o ?g. }
- W1421933048 abstract "Metabolic syndrome greatly increases the risk for developing metabolic and cardiovascular disorders and has reached epidemic proportions globally. Despite recent advances in medical science, scientific understandings on the root mechanisms of metabolic syndrome are still not fully understood, and such insufficient knowledge contributes to the relative lack of effective treatments for such diseases. Protein Kinase R (PKR) is a serine threonine kinase activated during various stress conditions. Activation of PKR can increase reactive oxygen product generation, cause oxidative stress and inflammation. In this review we discuss the potential role of PKR in metabolic syndrome, pathways activated by it and the interrelationship between pathways activated, modes of propagation if one of the pathways is inhibited or activated. Specific and effective inhibitors of PKR are being developed and can become potential treatment for metabolic syndrome and prevent many diseases." @default.
- W1421933048 created "2016-06-24" @default.
- W1421933048 creator A5011831819 @default.
- W1421933048 creator A5016868651 @default.
- W1421933048 creator A5025749067 @default.
- W1421933048 creator A5038938010 @default.
- W1421933048 creator A5065098588 @default.
- W1421933048 creator A5068245795 @default.
- W1421933048 creator A5090764423 @default.
- W1421933048 date "2015-07-16" @default.
- W1421933048 modified "2023-09-22" @default.
- W1421933048 title "Protein kinase R and the metabolic syndrome" @default.
- W1421933048 cites W1039166211 @default.
- W1421933048 cites W138849845 @default.
- W1421933048 cites W1565839478 @default.
- W1421933048 cites W1624106188 @default.
- W1421933048 cites W180682456 @default.
- W1421933048 cites W1975967072 @default.
- W1421933048 cites W1986925815 @default.
- W1421933048 cites W1994601555 @default.
- W1421933048 cites W1998334193 @default.
- W1421933048 cites W2000054651 @default.
- W1421933048 cites W2003607337 @default.
- W1421933048 cites W2018554539 @default.
- W1421933048 cites W2022846624 @default.
- W1421933048 cites W2027839715 @default.
- W1421933048 cites W2035477349 @default.
- W1421933048 cites W2039340278 @default.
- W1421933048 cites W2039613596 @default.
- W1421933048 cites W2040848606 @default.
- W1421933048 cites W2047391267 @default.
- W1421933048 cites W2048625405 @default.
- W1421933048 cites W2055976012 @default.
- W1421933048 cites W2056816617 @default.
- W1421933048 cites W2058982642 @default.
- W1421933048 cites W2063929139 @default.
- W1421933048 cites W2089198803 @default.
- W1421933048 cites W2091202795 @default.
- W1421933048 cites W2100275934 @default.
- W1421933048 cites W2103565638 @default.
- W1421933048 cites W2104462810 @default.
- W1421933048 cites W2107601804 @default.
- W1421933048 cites W2108736984 @default.
- W1421933048 cites W2111793830 @default.
- W1421933048 cites W2116648773 @default.
- W1421933048 cites W2124334491 @default.
- W1421933048 cites W2137834493 @default.
- W1421933048 cites W2143514809 @default.
- W1421933048 cites W2169472869 @default.
- W1421933048 doi "https://doi.org/10.3233/jcb-15006" @default.
- W1421933048 hasPublicationYear "2015" @default.
- W1421933048 type Work @default.
- W1421933048 sameAs 1421933048 @default.
- W1421933048 citedByCount "2" @default.
- W1421933048 countsByYear W14219330482017 @default.
- W1421933048 countsByYear W14219330482019 @default.
- W1421933048 crossrefType "journal-article" @default.
- W1421933048 hasAuthorship W1421933048A5011831819 @default.
- W1421933048 hasAuthorship W1421933048A5016868651 @default.
- W1421933048 hasAuthorship W1421933048A5025749067 @default.
- W1421933048 hasAuthorship W1421933048A5038938010 @default.
- W1421933048 hasAuthorship W1421933048A5065098588 @default.
- W1421933048 hasAuthorship W1421933048A5068245795 @default.
- W1421933048 hasAuthorship W1421933048A5090764423 @default.
- W1421933048 hasConcept C134018914 @default.
- W1421933048 hasConcept C161238802 @default.
- W1421933048 hasConcept C181199279 @default.
- W1421933048 hasConcept C184235292 @default.
- W1421933048 hasConcept C192989942 @default.
- W1421933048 hasConcept C203014093 @default.
- W1421933048 hasConcept C2776151105 @default.
- W1421933048 hasConcept C2776914184 @default.
- W1421933048 hasConcept C2777479484 @default.
- W1421933048 hasConcept C2780578515 @default.
- W1421933048 hasConcept C48349386 @default.
- W1421933048 hasConcept C55493867 @default.
- W1421933048 hasConcept C555293320 @default.
- W1421933048 hasConcept C60644358 @default.
- W1421933048 hasConcept C71924100 @default.
- W1421933048 hasConcept C82495950 @default.
- W1421933048 hasConcept C86803240 @default.
- W1421933048 hasConcept C90934575 @default.
- W1421933048 hasConcept C95444343 @default.
- W1421933048 hasConcept C97029542 @default.
- W1421933048 hasConceptScore W1421933048C134018914 @default.
- W1421933048 hasConceptScore W1421933048C161238802 @default.
- W1421933048 hasConceptScore W1421933048C181199279 @default.
- W1421933048 hasConceptScore W1421933048C184235292 @default.
- W1421933048 hasConceptScore W1421933048C192989942 @default.
- W1421933048 hasConceptScore W1421933048C203014093 @default.
- W1421933048 hasConceptScore W1421933048C2776151105 @default.
- W1421933048 hasConceptScore W1421933048C2776914184 @default.
- W1421933048 hasConceptScore W1421933048C2777479484 @default.
- W1421933048 hasConceptScore W1421933048C2780578515 @default.
- W1421933048 hasConceptScore W1421933048C48349386 @default.
- W1421933048 hasConceptScore W1421933048C55493867 @default.
- W1421933048 hasConceptScore W1421933048C555293320 @default.
- W1421933048 hasConceptScore W1421933048C60644358 @default.
- W1421933048 hasConceptScore W1421933048C71924100 @default.
- W1421933048 hasConceptScore W1421933048C82495950 @default.