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- W1421934701 abstract "Publisher Summary This chapter describes the action of Delta-9-tetrahydrocannabinol and neuronal membrane-bound enzymes. Delta-9-tetrahydrocannabinol (Δ-9-THC), the major pharmacologically active component of cannabis, produces characteristic changes in the activities of membrane bound enzymes of rat brain, under both in vivo and in vitro conditions. Acute Δ-9-THC administration produced stimulation of acetylcholine esterase and glutamine synthetase activities in both synaptosomal and microsomal fractions, whereas the Na + -K + -ATPase activity in synaptosomes was inhibited and in microsomal fractions was stimulated under the same experimental conditions. In vitro treatment with Δ-9-THC produced inhibitory effects on both synaptosomal and microsomal Na + -K + -ATPase activities, stimulatory effects on synaptosomal activities, and stimulatory effects on synaptosomal and microsomal glutamine synthetase activities." @default.
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- W1421934701 date "1975-01-01" @default.
- W1421934701 modified "2023-09-24" @default.
- W1421934701 title "Delta-9-tetrahydrocannabinoI action and neuronal membrane-bound enzymes" @default.
- W1421934701 doi "https://doi.org/10.1016/s0079-6123(08)63702-4" @default.
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- W1421934701 hasPublicationYear "1975" @default.
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