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• W142251350 abstract "Research Article1 December 1992free access Dominant-negative mutants of a yeast G-protein beta subunit identify two functional regions involved in pheromone signalling. E. Leberer E. Leberer Eukaryotic Genetics Group, National Research Council of Canada, Montreal, Quebec. Search for more papers by this author D. Dignard D. Dignard Eukaryotic Genetics Group, National Research Council of Canada, Montreal, Quebec. Search for more papers by this author L. Hougan L. Hougan Eukaryotic Genetics Group, National Research Council of Canada, Montreal, Quebec. Search for more papers by this author D.Y. Thomas D.Y. Thomas Eukaryotic Genetics Group, National Research Council of Canada, Montreal, Quebec. Search for more papers by this author M. Whiteway M. Whiteway Eukaryotic Genetics Group, National Research Council of Canada, Montreal, Quebec. Search for more papers by this author E. Leberer E. Leberer Eukaryotic Genetics Group, National Research Council of Canada, Montreal, Quebec. Search for more papers by this author D. Dignard D. Dignard Eukaryotic Genetics Group, National Research Council of Canada, Montreal, Quebec. Search for more papers by this author L. Hougan L. Hougan Eukaryotic Genetics Group, National Research Council of Canada, Montreal, Quebec. Search for more papers by this author D.Y. Thomas D.Y. Thomas Eukaryotic Genetics Group, National Research Council of Canada, Montreal, Quebec. Search for more papers by this author M. Whiteway M. Whiteway Eukaryotic Genetics Group, National Research Council of Canada, Montreal, Quebec. Search for more papers by this author Author Information E. Leberer1, D. Dignard1, L. Hougan1, D.Y. Thomas1 and M. Whiteway1 1Eukaryotic Genetics Group, National Research Council of Canada, Montreal, Quebec. The EMBO Journal (1992)11:4805-4813https://doi.org/10.1002/j.1460-2075.1992.tb05586.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The STE4 gene, which encodes the beta subunit of the mating response G-protein in the yeast Saccharomyces cerevisiae, was subjected to a saturation mutagenesis using ‘doped’ oligodeoxynucleotides. We employed a genetic screen to select dominant-negative STE4 mutants, which when overexpressed from the GAL1 promoter, interfered with the signalling function of the wild type protein. The identified inhibitory amino acid alterations define two small regions that are crucially involved in transmitting the mating signal from G beta to downstream components of the signalling pathway. These results underline the positive signalling role of yeast G beta and assign for the first time the positive signalling function of a G-protein beta subunit to specific structural features. Previous ArticleNext Article Volume 11Issue 131 December 1992In this issue RelatedDetailsLoading ..." @default.
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• W142251350 title "Dominant-negative mutants of a yeast G-protein beta subunit identify two functional regions involved in pheromone signalling." @default.
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