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- W142407246 abstract "This chapter describes the model systems for the study of androgen-regulated gene expression in the central nervous system (CNS). CNS is an androgen target organ. The ability of specific groups of neurons to concentrate radioactive androgens within cell nuclei was first described in the 1970s, and was shown to be widespread in vertebrates. Because many brain nuclei containing androgen-concentrating neurons had been shown to participate in androgen-regulated behaviors, a causal link between androgen concentration and androgen regulation was inferred, a link strengthened by observations that small implants of androgen into these brain nuclei could activate the relevant behaviors. From a molecular point of view, however, the mechanism of androgen action—particularly the identification of androgen-regulated genes—is very poorly understood. Understanding this set of issues is crucial to unraveling how these very powerful hormones act." @default.
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- W142407246 date "2002-01-01" @default.
- W142407246 modified "2023-10-16" @default.
- W142407246 title "Models Systems for the Study of Androgen-Regulated Gene Expression in the Central Nervous System" @default.
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- W142407246 doi "https://doi.org/10.1016/b978-012532104-4/50051-2" @default.
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