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• W142449597 abstract "textabstractThe insulin-like growth factors (IGFs) were first discovered in 1957 by Salmon andDaughaday (1957). They found that in vivo administration of growth hormone (GH)induced a serum factor capable of stimulating sulfate uptake in cartilage. In 1972 this'sulfation factor' was renamed somatomedin (mediator of the effects of somatotropin,GH) and classified as a growth factor (Daughaday et aI., 1972). At the same time, acompound named NSILA (nonsuppressible insulin-like activity) was found (Froesch et aI.,1966). NSILA and somatomedin each stimulated glucose incorporation into fat and sulfateincorporation into cartilage (Froesch et aI., 1976). The amino acid sequence of NSILAshowed 48% homology with human pro-insulin. Therefore it was called insulin-likegrowth factor-I (IGF-I) (Rinderknecht and Humbel, 1978a). A second bioactive insulin-likemolecule appeared to be similar, but not identical, and was named IGF-II (Rinderknechtand Humbel, 1978b). Somatomedin appeared to be identical to IGF-I (Svoboda et aI.,1980).Now, over forty years later, in vivo studies, gene expression experiments, anddetermination of signalling pathways have provided more insight into IGF actions. IGFreceptors and IGF binding proteins (IGFBPs) have been characterized (Chernausek et aI.,1981; Kasuga et aI., 1981; Brinkman et aI., 1988; Binkert et aI., 1989; Margot et aI.,1989; Shimasaki, 1989; Murphy et aI., 1990; Shimasaki, 1990; 1991a/b; Schuller et aI.,1994). This, and the recent discovery of IGFBP related proteins, have shown thecomplexity of the IGF system (Oh et aI., 1996). It is clear that the IGFs, together with theother IGF system compounds, playa pivotal role in body and organ development andgrowth.Therefore, this chapter will review in more detait characteristics of the separatecomponents of the IGF system. Then, focus is put on the IGF system during mousedevelopment. A summary of the data generated to elucidate the functions of the IGFsystem during mouse development is described." @default.
• W142449597 created "2016-06-24" @default.
• W142449597 creator A5079315623 @default.
• W142449597 date "1999-06-02" @default.
• W142449597 modified "2023-09-27" @default.
• W142449597 title "The IGF system during growth and differentiation of the mouse" @default.
• W142449597 cites W1481362782 @default.
• W142449597 cites W1489237025 @default.
• W142449597 cites W1500990165 @default.
• W142449597 cites W1569741533 @default.
• W142449597 cites W1585483493 @default.
• W142449597 cites W1921141222 @default.
• W142449597 cites W1948457293 @default.
• W142449597 cites W1964203795 @default.
• W142449597 cites W1964652533 @default.
• W142449597 cites W1965928098 @default.
• W142449597 cites W1970373283 @default.
• W142449597 cites W1972819401 @default.
• W142449597 cites W1977186059 @default.
• W142449597 cites W1980525261 @default.
• W142449597 cites W1980701912 @default.
• W142449597 cites W1984768175 @default.
• W142449597 cites W1986161955 @default.
• W142449597 cites W1986199420 @default.
• W142449597 cites W1987568997 @default.
• W142449597 cites W1987709138 @default.
• W142449597 cites W1989803336 @default.
• W142449597 cites W1990049285 @default.
• W142449597 cites W1991414708 @default.
• W142449597 cites W1991780769 @default.
• W142449597 cites W1992525855 @default.
• W142449597 cites W1995406396 @default.
• W142449597 cites W1998109631 @default.
• W142449597 cites W2000184714 @default.
• W142449597 cites W2001811508 @default.
• W142449597 cites W2004307717 @default.
• W142449597 cites W2004978370 @default.
• W142449597 cites W2005546345 @default.
• W142449597 cites W2006577883 @default.
• W142449597 cites W2007573212 @default.
• W142449597 cites W2008850214 @default.
• W142449597 cites W2010378575 @default.
• W142449597 cites W2011409454 @default.
• W142449597 cites W2011861484 @default.
• W142449597 cites W2014815828 @default.
• W142449597 cites W2015843482 @default.
• W142449597 cites W2016630162 @default.
• W142449597 cites W2017154680 @default.
• W142449597 cites W2019990928 @default.
• W142449597 cites W2021005975 @default.
• W142449597 cites W2022867908 @default.
• W142449597 cites W2025234765 @default.
• W142449597 cites W2035905548 @default.
• W142449597 cites W2036188996 @default.
• W142449597 cites W2038669400 @default.
• W142449597 cites W2039054907 @default.
• W142449597 cites W2039176414 @default.
• W142449597 cites W2041426179 @default.
• W142449597 cites W2042383730 @default.
• W142449597 cites W2057752917 @default.
• W142449597 cites W2057839777 @default.
• W142449597 cites W2060271719 @default.
• W142449597 cites W2060681672 @default.
• W142449597 cites W2061825537 @default.
• W142449597 cites W2064382466 @default.
• W142449597 cites W2066908611 @default.
• W142449597 cites W2067928197 @default.
• W142449597 cites W2068326310 @default.
• W142449597 cites W2070186740 @default.
• W142449597 cites W2070466664 @default.
• W142449597 cites W2070770454 @default.
• W142449597 cites W2071604946 @default.
• W142449597 cites W2072333923 @default.
• W142449597 cites W2072514327 @default.
• W142449597 cites W2073908723 @default.
• W142449597 cites W2074354156 @default.
• W142449597 cites W2076961833 @default.
• W142449597 cites W2077549378 @default.
• W142449597 cites W2077897607 @default.
• W142449597 cites W2078542512 @default.
• W142449597 cites W2080000569 @default.
• W142449597 cites W2080560090 @default.
• W142449597 cites W2081624146 @default.
• W142449597 cites W2083406280 @default.
• W142449597 cites W2084599608 @default.
• W142449597 cites W2089355300 @default.
• W142449597 cites W2090277249 @default.
• W142449597 cites W2094707609 @default.
• W142449597 cites W2097746620 @default.
• W142449597 cites W2098812740 @default.
• W142449597 cites W2105041057 @default.
• W142449597 cites W2108317548 @default.
• W142449597 cites W2114819696 @default.
• W142449597 cites W2115073960 @default.
• W142449597 cites W2118980160 @default.
• W142449597 cites W2125980420 @default.
• W142449597 cites W2126484796 @default.
• W142449597 cites W2126526170 @default.
• W142449597 cites W2127380756 @default.
• W142449597 cites W2127526484 @default.

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