Matches in SemOpenAlex for { <https://semopenalex.org/work/W142456989> ?p ?o ?g. }
- W142456989 endingPage "150" @default.
- W142456989 startingPage "139" @default.
- W142456989 abstract "Eukaryotic DNA is packaged into a nucleoprotein structure known as chromatin, which is comprised of DNA, histones, and nonhistone proteins. Chromatin structure is highly dynamic, and can shift from a transcriptionally inactive state to an active form in response to intra- and extracellular signals. A major factor in chromatin architecture is the covalent modification of histones through the addition of chemical moieties, such as acetyl, methyl, ubiquitin, and phosphate groups. The acetylation of the amino-terminal tails of histones is a process that is highly conserved in eukaryotes, and was one of the earliest histone modifications characterized. Since its identification in 1964, a large body of evidence has accumulated demonstrating that histone acetylation plays an important role in transcription. Despite our ever-growing understanding of the nuclear processes involved in nucleosome acetylation, however, the exact biochemical mechanisms underlying the downstream effects of histone acetylation have yet to be fully elucidated. To date, histone acetylation has been proposed to function in 2 nonmutually exclusive manners: by directly altering chromatin structure, and by acting as a molecular tag for the recruitment of chromatin-modifying complexes. Here, we discuss recent research focusing on these 2 potential roles of histone acetylation and clarify what we actually know about the function of this modification." @default.
- W142456989 created "2016-06-24" @default.
- W142456989 creator A5046732964 @default.
- W142456989 creator A5081887206 @default.
- W142456989 date "2009-02-01" @default.
- W142456989 modified "2023-10-01" @default.
- W142456989 title "Histone acetylation: truth of consequences?This paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process." @default.
- W142456989 cites W1509466986 @default.
- W142456989 cites W1540264737 @default.
- W142456989 cites W1586131224 @default.
- W142456989 cites W1609966422 @default.
- W142456989 cites W1629804770 @default.
- W142456989 cites W1722318356 @default.
- W142456989 cites W172975180 @default.
- W142456989 cites W1903120115 @default.
- W142456989 cites W1965582387 @default.
- W142456989 cites W1967578025 @default.
- W142456989 cites W1967596247 @default.
- W142456989 cites W1967769642 @default.
- W142456989 cites W1967903656 @default.
- W142456989 cites W1968894421 @default.
- W142456989 cites W1969438143 @default.
- W142456989 cites W1971407164 @default.
- W142456989 cites W1974229409 @default.
- W142456989 cites W1974426680 @default.
- W142456989 cites W1979187818 @default.
- W142456989 cites W1979470231 @default.
- W142456989 cites W1984762771 @default.
- W142456989 cites W1984793963 @default.
- W142456989 cites W1986411314 @default.
- W142456989 cites W1986606329 @default.
- W142456989 cites W1988495967 @default.
- W142456989 cites W1989819265 @default.
- W142456989 cites W1989842018 @default.
- W142456989 cites W1992902970 @default.
- W142456989 cites W1994059637 @default.
- W142456989 cites W1994577866 @default.
- W142456989 cites W1995668347 @default.
- W142456989 cites W1996270170 @default.
- W142456989 cites W1997478944 @default.
- W142456989 cites W1999952815 @default.
- W142456989 cites W2002698073 @default.
- W142456989 cites W2004767437 @default.
- W142456989 cites W2005723902 @default.
- W142456989 cites W2006225938 @default.
- W142456989 cites W2007684630 @default.
- W142456989 cites W2008284328 @default.
- W142456989 cites W2013050831 @default.
- W142456989 cites W2015197935 @default.
- W142456989 cites W2020740882 @default.
- W142456989 cites W2021207245 @default.
- W142456989 cites W2021825316 @default.
- W142456989 cites W2025909991 @default.
- W142456989 cites W2027592091 @default.
- W142456989 cites W2027804136 @default.
- W142456989 cites W2029521343 @default.
- W142456989 cites W2029903254 @default.
- W142456989 cites W2030808618 @default.
- W142456989 cites W2037516018 @default.
- W142456989 cites W2037623882 @default.
- W142456989 cites W2037794607 @default.
- W142456989 cites W2038990762 @default.
- W142456989 cites W2040540665 @default.
- W142456989 cites W2041803958 @default.
- W142456989 cites W2043679962 @default.
- W142456989 cites W2046079276 @default.
- W142456989 cites W2047824377 @default.
- W142456989 cites W2048350558 @default.
- W142456989 cites W2049868369 @default.
- W142456989 cites W2050069448 @default.
- W142456989 cites W2050377582 @default.
- W142456989 cites W2052837845 @default.
- W142456989 cites W2056727374 @default.
- W142456989 cites W2057916572 @default.
- W142456989 cites W2063679723 @default.
- W142456989 cites W2064792809 @default.
- W142456989 cites W2068507797 @default.
- W142456989 cites W2069328568 @default.
- W142456989 cites W2070359888 @default.
- W142456989 cites W2071955851 @default.
- W142456989 cites W2077026916 @default.
- W142456989 cites W2083085787 @default.
- W142456989 cites W2083245183 @default.
- W142456989 cites W2083279359 @default.
- W142456989 cites W2084601812 @default.
- W142456989 cites W2085299836 @default.
- W142456989 cites W2090098862 @default.
- W142456989 cites W2096083625 @default.
- W142456989 cites W2098665858 @default.
- W142456989 cites W2098952156 @default.
- W142456989 cites W2099565612 @default.
- W142456989 cites W2100285856 @default.
- W142456989 cites W2100716254 @default.
- W142456989 cites W2101461473 @default.
- W142456989 cites W2103302926 @default.
- W142456989 cites W2106317558 @default.
- W142456989 cites W2110312780 @default.
- W142456989 cites W2113062096 @default.