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- W142464615 abstract "The 3-aminoxy-(E)-2-methoxyiminopropionyl penicillins 13 and cephalosporins 14 and 15 were synthesized and assayed for their antimicrobial activity on Gram-positive and Gram-negative bacteria whether producers of β-lactamases or otherwise. Compounds 13, 14, and 15 exhibited an activity which was generally lower than that of the corresponding phenylacetyl derivative: penicillin G (4), cephaloram (5), and phenylacetamidodesacetoxycephalosporanic acid (6). Furthermore, the comparison of the minimum inhibitory concentration values of some of the new 2-methoxyimino 3-aminoxypropionyl derivatives 13–15 with those of the corresponding ones 1–3 lacking the 2-methoxyimino substituent showed that the introduction of the 2-methoxyimino group of E configuration on the aminoxypropionamido side chain of 1–3 gives compounds (13–15) which do not generally possess better antimicrobial properties. Les (E)-3-iminoxy-2-méthoxyimino propionyl pénicillines 13 et céphalosporines 14 et 15 ont été synthétisées et testées quant à leur activité antimicrobienne sur les bactéries Gram-positive et Gram-négative produisant ou non des β-lactamases. Les composés 13, 14, et 15 ont montré une activité généralement plus faible que celle du dérivé phénylacétylé correspondant: pénicilline G(4), céphalorame (5), et acide phénylacétamidodésacétoxycéphalosporanique (6). En outre, la comparaison des valeurs de concentration inhibitrice minimale de certains dérivés nouveaux: 2-méthoxyimino-3-aminoxy propionyl 13–15 avec celles des dérivés correspondants 1–3 sans substituant 2-méthoxyimino ont révélé que l'introduction du groupe 2-méthoxyimino de configuration E sur la chaîne latérale aminoxypropionyle de 1–3 donne des composés (13–15) qui ne possèdent généralement pas de meilleures propriétés antimicrobiennes." @default.
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- W142464615 date "1990-04-01" @default.
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- W142464615 title "Synthèses et propriétés antimicrobiennes de (E)-3-aminoxy-2-méthoxyimino propionyl pénicillines et céphalosporines" @default.
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- W142464615 doi "https://doi.org/10.1016/0223-5234(90)90205-h" @default.
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