Matches in SemOpenAlex for { <https://semopenalex.org/work/W142482983> ?p ?o ?g. }
- W142482983 endingPage "74" @default.
- W142482983 startingPage "1" @default.
- W142482983 abstract "This chapter reviews the studies on the mechanism of tumor promotion in mouse skin by croton oil and phorbol diesters and on the effects of these compounds on cell cultures of various types. The chapter discusses the findings in the field of tumor promoters during mid- 1979 and provides sources in the literature that are useful as background. For an historical perspective of the concept of two-stage carcinogenesis and tumor promotion are described. The demonstration of two distinct stages in experimentally induced cancer in animals suggests that there are two stages in environmentally induced cancer in humans. Tumor induction can be divided into two distinct treatment stages, initiation and promotion, and that the promotion stage is reversible. Compounds with tumor-promoting activity are a class of cocarcinogens that are not themselves mutagenic or carcinogenic but that cause the formation of tumors when applied repeatedly after an irreversible event has been initiated by a carcinogen. Prevention of human cancer requires the identification and, wherever possible, the elimination of these agents. Because promotion is a reversible process that requires repeated exposure over a period of time, in contrast to the rapid, irreversible process of initiation by carcinogens, manipulation of promotion would seem to be the best method of cancer prevention. The identification of promoters in the environment, and the elucidation of their mechanisms of action, could lead to prophylactic measures such as the development of drugs specifically designed to interfere with the promotion mechanism and prevent tumor formation." @default.
- W142482983 created "2016-06-24" @default.
- W142482983 creator A5026277311 @default.
- W142482983 creator A5071788992 @default.
- W142482983 creator A5073771007 @default.
- W142482983 date "1980-01-01" @default.
- W142482983 modified "2023-10-03" @default.
- W142482983 title "Tumor Promoters and the Mechanism of Tumor Promotion" @default.
- W142482983 cites W1505646268 @default.
- W142482983 cites W1547153486 @default.
- W142482983 cites W1552544560 @default.
- W142482983 cites W1558941327 @default.
- W142482983 cites W1565526431 @default.
- W142482983 cites W1583463849 @default.
- W142482983 cites W187198275 @default.
- W142482983 cites W1908609031 @default.
- W142482983 cites W1923728284 @default.
- W142482983 cites W1964222690 @default.
- W142482983 cites W1965571350 @default.
- W142482983 cites W1966373417 @default.
- W142482983 cites W1967237898 @default.
- W142482983 cites W1967304777 @default.
- W142482983 cites W1967518359 @default.
- W142482983 cites W1968028322 @default.
- W142482983 cites W1968101564 @default.
- W142482983 cites W1968990741 @default.
- W142482983 cites W1969206047 @default.
- W142482983 cites W1969665533 @default.
- W142482983 cites W1969951421 @default.
- W142482983 cites W1970030444 @default.
- W142482983 cites W1970264664 @default.
- W142482983 cites W1970664442 @default.
- W142482983 cites W1970733758 @default.
- W142482983 cites W1971533714 @default.
- W142482983 cites W1971618858 @default.
- W142482983 cites W1972020763 @default.
- W142482983 cites W1973838327 @default.
- W142482983 cites W1973907819 @default.
- W142482983 cites W1974096267 @default.
- W142482983 cites W1976750101 @default.
- W142482983 cites W1977382255 @default.
- W142482983 cites W1978920523 @default.
- W142482983 cites W1979704489 @default.
- W142482983 cites W1979870899 @default.
- W142482983 cites W1983043038 @default.
- W142482983 cites W1984017575 @default.
- W142482983 cites W1984414858 @default.
- W142482983 cites W1985127862 @default.
- W142482983 cites W1985272742 @default.
- W142482983 cites W1985534773 @default.
- W142482983 cites W1986642717 @default.
- W142482983 cites W1987193104 @default.
- W142482983 cites W1988310174 @default.
- W142482983 cites W1989891172 @default.
- W142482983 cites W1993052466 @default.
- W142482983 cites W1993169352 @default.
- W142482983 cites W1993709334 @default.
- W142482983 cites W1995154978 @default.
- W142482983 cites W1997194461 @default.
- W142482983 cites W1998819472 @default.
- W142482983 cites W1999689481 @default.
- W142482983 cites W2000976891 @default.
- W142482983 cites W2001265061 @default.
- W142482983 cites W2002001183 @default.
- W142482983 cites W2002843141 @default.
- W142482983 cites W2003947409 @default.
- W142482983 cites W2004378795 @default.
- W142482983 cites W2005067189 @default.
- W142482983 cites W2005730116 @default.
- W142482983 cites W2006084058 @default.
- W142482983 cites W2006763342 @default.
- W142482983 cites W2007001153 @default.
- W142482983 cites W2007459944 @default.
- W142482983 cites W2007818366 @default.
- W142482983 cites W2008737422 @default.
- W142482983 cites W2009790796 @default.
- W142482983 cites W2010317056 @default.
- W142482983 cites W2011605356 @default.
- W142482983 cites W2011699709 @default.
- W142482983 cites W2011807027 @default.
- W142482983 cites W2012556416 @default.
- W142482983 cites W2013028390 @default.
- W142482983 cites W2013704122 @default.
- W142482983 cites W2014520088 @default.
- W142482983 cites W2017113575 @default.
- W142482983 cites W2017138388 @default.
- W142482983 cites W2018550630 @default.
- W142482983 cites W2018786770 @default.
- W142482983 cites W2020873813 @default.
- W142482983 cites W2021891202 @default.
- W142482983 cites W2022288648 @default.
- W142482983 cites W2024083201 @default.
- W142482983 cites W2025301514 @default.
- W142482983 cites W2027576790 @default.
- W142482983 cites W2027672656 @default.
- W142482983 cites W2028569687 @default.
- W142482983 cites W2029770423 @default.
- W142482983 cites W2030633235 @default.