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- W142488660 abstract "If a single living muscle is excised and stimulated by an electric current it can be made to contract. If the stimulation is repeated often enough the contractions will become more and more feeble and finally cease. The muscle is said to be fatigued. The energy for contraction was supplied by the conversion of glycogen into lactic acid. The complete fatigue is due to the fact that the hydrogen-ion concentration has risen to such a point that no more glycogen can be converted into lactic acid. During rest, with an adequate supply of oxygen, sugar, and bases to replenish the alkali reserve, the lactic acid is reconverted into glycogen and recovery is soon complete. No analogous production of complete muscle fatigue ever occurs in the human being and yet the symptom of fatigue is often considered and treated in the light of this simple experiment. An additional factor is often postulated, namely, that the blood supply is inadequate in that it may contain some toxic agent, as in hyperthyroidism or be deficient qualitatively, as in pernicious anaemia. Often that is true. If we stimulate the excised muscle by way of its nerve in the same fashion, we find that the same phenomenon occurs, namely, that after a few stimulations the muscle will stop contracting. However, if we at once change the stimulation from the nerve to the muscle, the muscle will again contract and continues until entirely fatigued. This shows that the nerve fibres fatigued before the muscle. If, in a third instance, the stimulus for muscle contraction is done by the mind through the nerve path to the muscle, we find that the subject" @default.
- W142488660 created "2016-06-24" @default.
- W142488660 creator A5055039996 @default.
- W142488660 date "1942-07-01" @default.
- W142488660 modified "2023-09-23" @default.
- W142488660 title "Fatigue, Rest and Exercise." @default.
- W142488660 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1827271" @default.
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