Matches in SemOpenAlex for { <https://semopenalex.org/work/W142554672> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W142554672 endingPage "7" @default.
- W142554672 startingPage "91" @default.
- W142554672 abstract "We studied the incidence and significance of tumor cell contamination of the bone marrow or peripheral blood progenitor cells of patients who had high risk primary breast cancer involving 10 or more axillary lymph nodes and who received high dose cyclophosphamide, cisplatin, and carmustine with hematopoietic support as consolidation following standard dose adjuvant chemotherapy. The autologous hematopoietic cell products were evaluated in 85 eligible patients. Eighty-three samples were available from the time of bone marrow harvest, and peripheral blood progenitor cells were evaluated from 57 of the 65 patients who additionally received these products. The screening technique utilized a panel of four anti-breast cancer monoclonal antibodies and an immunohistochemical technique. Thirty (36%) of the 83 evaluable patients had tumor cell contamination of the bone marrow. Only 2 (4%) of the 57 patients had tumor cell contamination of the peripheral blood progenitor cells. Tumor cell contamination of the bone marrow was associated with shorter disease-free survival and overall survival. In addition, the higher the number of tumor cells identified, the shorter disease-free and overall survival. There was no relationship between the tumor cell contamination of the bone marrow and the site of relapse. The combination of the log of the number of tumor cells +1 and number of positive lymph nodes predicted both disease-free and overall survival. Tumor cell contamination of the bone marrow from the harvest is associated with shorter disease-free and overall survival for patients who were treated with standard dose chemotherapy followed by consolidation with high dose alkylating agents and hematopoietic support. It is unclear what role the contaminating tumor cells have in relapse, and they may just be a high-risk marker. A comparison with other prognostic factors and characteristics of the tumor may determine the significance of the tumor contamination of the bone marrow." @default.
- W142554672 created "2016-06-24" @default.
- W142554672 creator A5011457263 @default.
- W142554672 creator A5014505996 @default.
- W142554672 creator A5029186084 @default.
- W142554672 creator A5058676347 @default.
- W142554672 creator A5061136699 @default.
- W142554672 creator A5062031844 @default.
- W142554672 creator A5067595997 @default.
- W142554672 creator A5070855401 @default.
- W142554672 creator A5073571977 @default.
- W142554672 date "1997-06-01" @default.
- W142554672 modified "2023-09-26" @default.
- W142554672 title "The significance of tumor contamination in the bone marrow from high-risk primary breast cancer patients treated with high-dose chemotherapy and hematopoietic support." @default.
- W142554672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9267669" @default.
- W142554672 hasPublicationYear "1997" @default.
- W142554672 type Work @default.
- W142554672 sameAs 142554672 @default.
- W142554672 citedByCount "13" @default.
- W142554672 crossrefType "journal-article" @default.
- W142554672 hasAuthorship W142554672A5011457263 @default.
- W142554672 hasAuthorship W142554672A5014505996 @default.
- W142554672 hasAuthorship W142554672A5029186084 @default.
- W142554672 hasAuthorship W142554672A5058676347 @default.
- W142554672 hasAuthorship W142554672A5061136699 @default.
- W142554672 hasAuthorship W142554672A5062031844 @default.
- W142554672 hasAuthorship W142554672A5067595997 @default.
- W142554672 hasAuthorship W142554672A5070855401 @default.
- W142554672 hasAuthorship W142554672A5073571977 @default.
- W142554672 hasConcept C109159458 @default.
- W142554672 hasConcept C121608353 @default.
- W142554672 hasConcept C126322002 @default.
- W142554672 hasConcept C142724271 @default.
- W142554672 hasConcept C143998085 @default.
- W142554672 hasConcept C201750760 @default.
- W142554672 hasConcept C2776694085 @default.
- W142554672 hasConcept C2776755627 @default.
- W142554672 hasConcept C2777649267 @default.
- W142554672 hasConcept C2780007613 @default.
- W142554672 hasConcept C2780147359 @default.
- W142554672 hasConcept C28328180 @default.
- W142554672 hasConcept C530470458 @default.
- W142554672 hasConcept C54355233 @default.
- W142554672 hasConcept C71924100 @default.
- W142554672 hasConcept C86803240 @default.
- W142554672 hasConceptScore W142554672C109159458 @default.
- W142554672 hasConceptScore W142554672C121608353 @default.
- W142554672 hasConceptScore W142554672C126322002 @default.
- W142554672 hasConceptScore W142554672C142724271 @default.
- W142554672 hasConceptScore W142554672C143998085 @default.
- W142554672 hasConceptScore W142554672C201750760 @default.
- W142554672 hasConceptScore W142554672C2776694085 @default.
- W142554672 hasConceptScore W142554672C2776755627 @default.
- W142554672 hasConceptScore W142554672C2777649267 @default.
- W142554672 hasConceptScore W142554672C2780007613 @default.
- W142554672 hasConceptScore W142554672C2780147359 @default.
- W142554672 hasConceptScore W142554672C28328180 @default.
- W142554672 hasConceptScore W142554672C530470458 @default.
- W142554672 hasConceptScore W142554672C54355233 @default.
- W142554672 hasConceptScore W142554672C71924100 @default.
- W142554672 hasConceptScore W142554672C86803240 @default.
- W142554672 hasIssue "2" @default.
- W142554672 hasLocation W1425546721 @default.
- W142554672 hasOpenAccess W142554672 @default.
- W142554672 hasPrimaryLocation W1425546721 @default.
- W142554672 hasRelatedWork W1987997012 @default.
- W142554672 hasRelatedWork W1994740289 @default.
- W142554672 hasRelatedWork W2007779610 @default.
- W142554672 hasRelatedWork W2019694705 @default.
- W142554672 hasRelatedWork W2083298077 @default.
- W142554672 hasRelatedWork W2157990290 @default.
- W142554672 hasRelatedWork W2166113699 @default.
- W142554672 hasRelatedWork W2795180021 @default.
- W142554672 hasRelatedWork W2890587470 @default.
- W142554672 hasRelatedWork W3031417299 @default.
- W142554672 hasVolume "3" @default.
- W142554672 isParatext "false" @default.
- W142554672 isRetracted "false" @default.
- W142554672 magId "142554672" @default.
- W142554672 workType "article" @default.