Matches in SemOpenAlex for { <https://semopenalex.org/work/W142585557> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W142585557 endingPage "5" @default.
- W142585557 startingPage "370" @default.
- W142585557 abstract "Spondyloarthropathies are a heterogeneous group of rheumatic disorders that commonly present with axial skeleton or sacroiliac joints involvement. Ocular involvement like uveitis, iritis and conjunctivitis can be present in up to a third of the patients. Genetic factors play a part in the pathogenesis of spondyloarthropathies. Association with the HLA-B27 gene, especially that between ankylosing spondylitis and HLA-B27 antigenic positivity, is one of the strongest association seen between a disease and a Class I antigen. This paper aims to review the frequencies of HLA-B27 gene and its subtypes in different population groups, possible mechanisms leading to the development of joint inflammation and the risk it confers for development of spondyloarthropathies.The MEDLINE database was searched using keywords: HLA-B27, spondyloarthropathy, molecular mimicry, arthritogenic peptides, reactive arthritis and ankylosing arthritis. Related articles for selected papers were also consulted. Books on HLA-B27 and spondyloarthropathy were obtained through the NUS Medical Library's LINC system.The genetic subtypes and susceptibility to development of disease vary in different population groups. Other HLA genes and non-HLA genes also play a part in the development of spondyloarthropathies, especially in those who are HLA-B27 negative. HLA-B27-positive relatives of spondyloarthritics have a higher risk of developing a similar condition. The presence of the HLA-B27 gene may serve as an aid to diagnosis or prognosis for clinicians. In juvenile arthritic patients, it is a poor prognostic factor, predicting for disease severity. It is also associated with poor outcomes for patients with anterior uveitis. However screening of asymptomatic individuals for the HLA-B27 gene is not recommended.The polygenic nature of the disease needs further elucidation and study." @default.
- W142585557 created "2016-06-24" @default.
- W142585557 creator A5089084800 @default.
- W142585557 date "2000-05-01" @default.
- W142585557 modified "2023-09-29" @default.
- W142585557 title "The genetics of spondyloarthropathies." @default.
- W142585557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10976392" @default.
- W142585557 hasPublicationYear "2000" @default.
- W142585557 type Work @default.
- W142585557 sameAs 142585557 @default.
- W142585557 citedByCount "1" @default.
- W142585557 countsByYear W1425855572023 @default.
- W142585557 crossrefType "journal-article" @default.
- W142585557 hasAuthorship W142585557A5089084800 @default.
- W142585557 hasConcept C126322002 @default.
- W142585557 hasConcept C147483822 @default.
- W142585557 hasConcept C188280979 @default.
- W142585557 hasConcept C203014093 @default.
- W142585557 hasConcept C2776194053 @default.
- W142585557 hasConcept C2776260265 @default.
- W142585557 hasConcept C2776661782 @default.
- W142585557 hasConcept C2777077863 @default.
- W142585557 hasConcept C2777365958 @default.
- W142585557 hasConcept C2777402515 @default.
- W142585557 hasConcept C2778091532 @default.
- W142585557 hasConcept C2778579456 @default.
- W142585557 hasConcept C2779134260 @default.
- W142585557 hasConcept C2779650986 @default.
- W142585557 hasConcept C2780131103 @default.
- W142585557 hasConcept C2908647359 @default.
- W142585557 hasConcept C2909797730 @default.
- W142585557 hasConcept C71924100 @default.
- W142585557 hasConcept C99454951 @default.
- W142585557 hasConceptScore W142585557C126322002 @default.
- W142585557 hasConceptScore W142585557C147483822 @default.
- W142585557 hasConceptScore W142585557C188280979 @default.
- W142585557 hasConceptScore W142585557C203014093 @default.
- W142585557 hasConceptScore W142585557C2776194053 @default.
- W142585557 hasConceptScore W142585557C2776260265 @default.
- W142585557 hasConceptScore W142585557C2776661782 @default.
- W142585557 hasConceptScore W142585557C2777077863 @default.
- W142585557 hasConceptScore W142585557C2777365958 @default.
- W142585557 hasConceptScore W142585557C2777402515 @default.
- W142585557 hasConceptScore W142585557C2778091532 @default.
- W142585557 hasConceptScore W142585557C2778579456 @default.
- W142585557 hasConceptScore W142585557C2779134260 @default.
- W142585557 hasConceptScore W142585557C2779650986 @default.
- W142585557 hasConceptScore W142585557C2780131103 @default.
- W142585557 hasConceptScore W142585557C2908647359 @default.
- W142585557 hasConceptScore W142585557C2909797730 @default.
- W142585557 hasConceptScore W142585557C71924100 @default.
- W142585557 hasConceptScore W142585557C99454951 @default.
- W142585557 hasIssue "3" @default.
- W142585557 hasLocation W1425855571 @default.
- W142585557 hasOpenAccess W142585557 @default.
- W142585557 hasPrimaryLocation W1425855571 @default.
- W142585557 hasRelatedWork W1409200180 @default.
- W142585557 hasRelatedWork W142585557 @default.
- W142585557 hasRelatedWork W1995132754 @default.
- W142585557 hasRelatedWork W2017822088 @default.
- W142585557 hasRelatedWork W2018258197 @default.
- W142585557 hasRelatedWork W2298016 @default.
- W142585557 hasRelatedWork W2412489449 @default.
- W142585557 hasRelatedWork W2968387725 @default.
- W142585557 hasRelatedWork W3196794760 @default.
- W142585557 hasRelatedWork W4210455900 @default.
- W142585557 hasVolume "29" @default.
- W142585557 isParatext "false" @default.
- W142585557 isRetracted "false" @default.
- W142585557 magId "142585557" @default.
- W142585557 workType "article" @default.