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• W142700705 abstract "Back to table of contents Previous article Next article No AccessClinical and neurochemical effects of fenfluramine in children with autismPublished Online:1 Apr 2006https://doi.org/10.1176/jnp.5.3.307AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractFifteen children with autism were treated with 60 mg d,l-fenfluramine (FEN) or placebo in a double-blind A-B-A protocol followed immediately by double-blind placebo-controlled crossover administration of FEN (total duration 62 weeks). Both biochemical and clinical outcomes were examined. Biochemically, FEN led to an increase in dihydroxyphenylacetic acid (DOPAC) and decreases in whole-blood serotonin (5-HT), plasma norepinephrine (NE), and plasma 3-methoxy-4- hydroxyphenylglycol (MHPG). The decrease in whole-blood 5-HT was seen only during treatment with FEN. However, NE levels did not return to baseline as long as 8 weeks after the first FEN treatment period. Increases in DOPAC were greater during the second FEN treatment period than the first. Persistent changes in catecholamine regulation may be related to previously reported long-term effects on central nervous system 5-HT after FEN. Clinically, FEN led to a modest decrease in parent, but not teacher, ratings of hyperactivity and to a small reduction in sensorimotor abnormalities. Abnormal social and affectual responses also decreased, but this was not directly related to FEN treatment. Effects on cognition were equivocal. Hyperserotonemic subjects did not differ from normoserotonemic subjects in clinical response. Overall, no significant advantage for the use of FEN could be established. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - Journal of Neuropsychiatry and Clinical Neurosciences $35.00 Add to cart PPV Articles - Journal of Neuropsychiatry and Clinical Neurosciences Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited byAntidepressants12 August 2022Case Reports in Psychiatry, Vol. 2018Current Psychiatry Reports, Vol. 16, No. 3Child and Adolescent Psychopharmacology News, Vol. 19, No. 1Cochrane Database of Systematic ReviewsDrugs, Vol. 73, No. 4The Autistic Spectrum Disorders30 March 2012Expert Opinion on Drug Discovery, Vol. 7, No. 5Evidence-Based Child Health: A Cochrane Review Journal, Vol. 6, No. 4Current Psychiatry Reports, Vol. 13, No. 3Annals of the New York Academy of Sciences, Vol. 1139, No. 1Mental Retardation and Developmental Disabilities Research Reviews, Vol. 10, No. 2Mental Retardation and Developmental Disabilities Research Reviews, Vol. 9, No. 3CNS Spectrums, Vol. 7, No. 9Pharmacological interventions for neurodevelopmental disordersJournal of the American Academy of Child & Adolescent Psychiatry, Vol. 40, No. 11Journal of Clinical Child & Adolescent Psychology, Vol. 30, No. 1Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 39, No. 9Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 38, No. 12The Neurobiology of Stereotypic Behaviors and Stereotypic Movement DisordersPsychiatric Annals, Vol. 28, No. 6Treatment of Autistic DisorderJournal of the American Academy of Child & Adolescent Psychiatry, Vol. 35, No. 2Psychopharmacology in Child and Adolescent Psychiatry: A Review of the Past Seven Years. Part IJournal of the American Academy of Child & Adolescent Psychiatry, Vol. 34, No. 9Child and Adolescent Psychiatric Clinics of North America, Vol. 4, No. 2 Volume 5Issue 3 August 1993Pages 307-315 Metrics PDF download History Published online 1 April 2006 Published in print 1 August 1993" @default.
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• W142700705 title "Clinical and neurochemical effects of fenfluramine in children with autism" @default.
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