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- W142716016 abstract "In the last 5 years, a large number of trials have been undertaken for the clinical application of cell-based therapy with human mesenchymal stromal cells (MSCs) for a variety of human autoimmune and degenerative diseases. In preclinical and clinical studies with ischemic injury, diabetes, wound healing, graft versus host disease, MSCs are emerging as promising candidates with therapeutic potential. MSC features such as homing efficiency to injured site, ability to produce several trophic factors in critical quantities needed for repair, immunomodulatory features to facilitate engraftment are expected to be the underlying mechanisms for therapeutic benefit in these disease states. Although early results are promising, much work is required as cellular therapies need careful isolation of cells, expansion, characterization, and proper delivery of injectable transplant ready cells that need to be prepared in good manufacturing practice (GMP) conditions to meet the safety and specification, reproducibility with no or minimal lot-to-lot variation, and efficacy following transplantation in to disease subjects. There have been 230 clinical trials as of April 2012 with MSCs that have been registered with Food and Drug Administration (FDA) site in various stages of investigation with autologus as well as allogenic sources of bone marrow-derived cells. This review summarizes the outcome of the completed trials and lays foundation for the expected outcome of the ongoing trials." @default.
- W142716016 created "2016-06-24" @default.
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- W142716016 date "2012-09-27" @default.
- W142716016 modified "2023-09-25" @default.
- W142716016 title "Mesenchymal Stromal Cells in the Clinic: What Do the Clinical Trials Say?" @default.
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- W142716016 doi "https://doi.org/10.1007/978-1-62703-200-1_19" @default.
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