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- W1427181771 abstract "Publisher Summary This chapter focuses on the role of factor VIII and factor VIIIa present in blood. The factor VIIIa apparently alters the active site structure of factor IXa to make it recognize the rate-limiting transition state for factor X activation, because its dominant kinetic effect is to increase the kcat. This chapter discusses the structure of factor VIII. Electrophoretic analysis of factor VIII preparations is commonly used to evaluate impurities and to determine whether factor VIII has been unintentionally activated. Assays for factor VIII coagulant function continue to play an important role in the assessment of factor VIII preparations. These assays are based on the ability of factor VIII to shorten the clotting time of plasma derived from a patient with hemophilia A. Two types of assays are commonly employed: the one-stage assay and the two-stage assay. The ability to modify a protein covalently at unique locations with fluorescence reporter groups can provide information on intra- and inter-molecular interactions. Factor VIII possesses no active site so that labeling at a single, unique position is difficult." @default.
- W1427181771 created "2016-06-24" @default.
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- W1427181771 date "1993-01-01" @default.
- W1427181771 modified "2023-09-23" @default.
- W1427181771 title "[7] Factor VIII and factor VIIIa" @default.
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- W1427181771 doi "https://doi.org/10.1016/0076-6879(93)22010-d" @default.
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