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• W1427208518 endingPage "1236" @default.
• W1427208518 startingPage "1229" @default.
• W1427208518 abstract "Caenorhabditis elegans BLMP-1 is the homolog of mammalian PRDM1/BLIMP1 transcriptional repressor and a component of the heterochronic pathway regulating developmental timing. We found that BLMP-1 positively and directly regulates the bed-3 gene required for vulval cell division and molting. blmp-1 mutation or RNAi reduces bed-3 reporter expression and causes phenotype similar to bed-3 mutations. We mapped an enhancer element responsible for bed-3 expression in the vulva and the hypodermis to a 200 bp region in the third intron. Using EMSA, we identified BLMP-1 binding sites within this region. Mutating these sites abolished both in vitro BLMP-1 binding and in vivo enhancer activity. Thus, BLMP-1 directly and positively regulates bed-3 transcription, connecting the heterochronic pathway to regulation of vulval cell division and molting. Recently, C. elegans blmp-1 was found to act as a transcriptional repressor. Thus, C. elegans BLMP-1 acts as a transcriptional activator or a repressor depending on the context." @default.
• W1427208518 created "2016-06-24" @default.
• W1427208518 creator A5004758996 @default.
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• W1427208518 date "2015-09-01" @default.
• W1427208518 modified "2023-10-13" @default.
• W1427208518 title "Direct and positive regulation of Caenorhabditis elegans bed-3 by PRDM1/BLIMP1 ortholog BLMP-1" @default.
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• W1427208518 doi "https://doi.org/10.1016/j.bbagrm.2015.07.012" @default.
• W1427208518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26234645" @default.
• W1427208518 hasPublicationYear "2015" @default.
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