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- W1427334861 abstract "AIM: The purpose of this experiment was to determine whether or not Enterobacter aerogenes, Acinetobacter baumannii, and Klebsiella pneumoniae, which are three gram negative bacteria commonly found on the skin, utilize fatty acids in a manner that affects bacterial phenotype. Furthermore, an objective was to gain a deeper understanding of how the alteration of bacterial membranes, as a result of fatty acid uptake, affected the pathogenicity, membrane permeability, and resistance in gram negative bacteria. METHODS: The lipids were extracted using the method of Bligh and Dyer and analyzed using thin-layer chromatography (TLC). A series of tests were performed, including a hydrophobic compound uptake test, lactic acid stress test, and osmotic pressure stress test, before analyzing lipids with high performance liquid chromatography (HPLC). RESULTS: TLC of isolated phospholipids from E. aerogenes, K. pneumoniae, and A. baumannii revealed an altered phospholipid migrational pattern when micromolar concentrations of γ-linolenic acid were supplemented to the growth media. When 18:3 was added to A. baumannii, there was decreased uptake of hydrophobic compounds, decreased membrane permeability, and better survivability under osmotic pressure and lactic acid stress. Addition of linoleic acid (18:2) did not affect the permeability as much as addition of γ-linolenic (18:3) or dihomo-γ-linolenic acid (20:3). CONCLUSION: A. baumannii alters its membrane according to exogenous fatty acid unsaturation and acyl chain length. Exposure of A. baumannii to three fatty acids resulted in an ability for the bacteria to uptake hydrophobic compounds. Since A. baumannii is a multiple drug resistant nosocomial pathogen, it is significant that its exposure to lotioncontaining (and host-derived) fatty acids and salt can make the bacteria more refractive to hydrophobic compounds, as well as impact stress survival in vitro." @default.
- W1427334861 created "2016-06-24" @default.
- W1427334861 creator A5074877857 @default.
- W1427334861 date "2015-01-01" @default.
- W1427334861 modified "2023-09-23" @default.
- W1427334861 title "The effects of lotion fatty acids on gram negative skin flora: implications for membrane remodeling and pathogenicity" @default.
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