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- W1427983835 abstract "This chapter discusses that the small DNA virus SV40 provides an excellent model for the analysis of the structure and mechanism of expression of genes functioning in the nucleus of an animal cell. The virus code for a protein of mass no more than 170,000 daltons; over one-third of this consists of capsid proteins that are formed only after DNA replication has begun. Presumably, the processes involved in “early” gene expression and most of those for “late” gene expression are available and utilized for host genes also, so that detailed knowledge of SV40 could provide appropriate analogs for the function of host cell genes. The chapter analyzes the cytoplasmic polyadenylate-containing RNA in cells infected with SV40, to locate the precise sequences of the genome encoding the 3' and 5' ends of cytoplasmic RNA. It examines the nucleotide sequences of the SV40 DNA overlapping the regions. Analyses were performed both on RNA transcripts of restriction fragments of the virus DNA and directly on the DNA. Interpretation of the results is limited, in that the sites of initiation and termination of transcription on viral DNA may not correspond to the ends of the cytoplasmic RNA because of possible nucleolytic processing of precursors. It reviews that certain analogies can be noted between untranslated sequences in SV40 and sequences at the ends of prokaryotic DNA transcripts." @default.
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- W1427983835 date "1977-01-01" @default.
- W1427983835 modified "2023-10-16" @default.
- W1427983835 title "The Primary Structure of Regions of SV40 DNA Encoding the Ends of mRNA" @default.
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- W1427983835 doi "https://doi.org/10.1016/s0079-6603(08)60916-2" @default.
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