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- W1428544057 abstract "为了延长白细胞介素受体-1拮抗剂（IL-1Ra）的血浆半衰期及组织特异性以达到更好的疗效，构建了通过连接肽相连的重组人IL-1Ra和人血清白蛋白的融合蛋白（IL-1Ra—HSA）的表达载体，并在毕赤酵母中获得了融合蛋白的高效分泌表达，表达产物经鉴定和纯化制备后，进行了生物学活性和药动学分析。结果表明，融合蛋白保留了IL-1Ra的拮抗剂活性，能特异性结合人黑色素细胞A375．S2的IL-1受体，有效抑制IL-1β诱导人黑色素细胞A375．S2的凋亡；同时，HSA的融合延长了IL-1Ra血浆半衰期（30倍），显著提高了IL-1Ra在炎症关节的摄取和保留时间，降低了IL-1Ra在其他组织如肝、肾、脾、肺的分布，表明融合蛋白在类风湿关节炎及其他与IL-1功能失调的免疫炎症性疾病的治疗上具有更好的应用前景。" @default.
- W1428544057 created "2016-06-24" @default.
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- W1428544057 date "2012-01-01" @default.
- W1428544057 modified "2023-09-22" @default.
- W1428544057 title "IL-1Ra-HSA融合蛋白的构建、生物学活性和药动学分析" @default.
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