Matches in SemOpenAlex for { <https://semopenalex.org/work/W142872013> ?p ?o ?g. }
- W142872013 abstract "The kidney is commonly affected in thrombotic thrombocytopenic purpura (TTP), a multi-system disorder with microvascular thrombosis of the capillaries and arterioles. Nevertheless, due to difference in its diagnostic criteria, the frequency and severity of renal dysfunction in TTP remains controversial. Recent studies indicate that the severe deficiency of a von Willebrand factor (VWF) cleaving protease, ADAMTS13, is the main cause of platelet thrombosis in TTP; it is now possible to define TTP at the molecular level. Among patients with acquired TTP due to inhibitory antibodies of ADAMTS13, renal dysfunction is usually mild; oliguria, fluid overload, hypertension, and need of dialysis support are infrequent. When any of these complications occur, one must re-examine the diagnosis of TTP and consider the possibility that the patient has another cause for these complications. In a patient with hereditary TTP, acute renal failure may ensue. However, the renal dysfunction is mostly reversible if the patients are promptly treated with plasma to replenish ADAMTS13. Patients with TTP, particularly of the hereditary type, may develop chronic renal failure. This complication may be a consequence of repeated insults by overt or subclinical microvascular thrombosis to the kidney, or it may have a separate cause. Therapy of hereditary TTP should aim not only to prevent acute exacerbations but also to minimize the risk of irreversible renal injury." @default.
- W142872013 created "2016-06-24" @default.
- W142872013 creator A5027737866 @default.
- W142872013 date "2007-12-01" @default.
- W142872013 modified "2023-09-29" @default.
- W142872013 title "The kidney in thrombotic thrombocytopenic purpura." @default.
- W142872013 cites W140077311 @default.
- W142872013 cites W1530308945 @default.
- W142872013 cites W1581006855 @default.
- W142872013 cites W1586475557 @default.
- W142872013 cites W1626846833 @default.
- W142872013 cites W164651796 @default.
- W142872013 cites W1819373183 @default.
- W142872013 cites W1831354387 @default.
- W142872013 cites W1964569129 @default.
- W142872013 cites W1966002084 @default.
- W142872013 cites W1966590389 @default.
- W142872013 cites W1968644067 @default.
- W142872013 cites W1969172216 @default.
- W142872013 cites W1974010028 @default.
- W142872013 cites W1975771188 @default.
- W142872013 cites W1976598369 @default.
- W142872013 cites W1977024178 @default.
- W142872013 cites W1977405768 @default.
- W142872013 cites W1977622626 @default.
- W142872013 cites W1978858820 @default.
- W142872013 cites W1979089312 @default.
- W142872013 cites W1979134309 @default.
- W142872013 cites W1980315401 @default.
- W142872013 cites W1980762761 @default.
- W142872013 cites W1983360433 @default.
- W142872013 cites W1993820365 @default.
- W142872013 cites W2001734004 @default.
- W142872013 cites W2002910801 @default.
- W142872013 cites W2009747114 @default.
- W142872013 cites W2016820387 @default.
- W142872013 cites W2025465156 @default.
- W142872013 cites W2026211638 @default.
- W142872013 cites W2026994059 @default.
- W142872013 cites W2032471106 @default.
- W142872013 cites W2035667239 @default.
- W142872013 cites W2038751184 @default.
- W142872013 cites W2038935774 @default.
- W142872013 cites W2044505929 @default.
- W142872013 cites W2045488836 @default.
- W142872013 cites W2050360519 @default.
- W142872013 cites W2052418612 @default.
- W142872013 cites W2052449117 @default.
- W142872013 cites W2056033242 @default.
- W142872013 cites W2057992498 @default.
- W142872013 cites W2059727759 @default.
- W142872013 cites W2060929250 @default.
- W142872013 cites W2061532259 @default.
- W142872013 cites W2062062973 @default.
- W142872013 cites W2067666104 @default.
- W142872013 cites W2069779742 @default.
- W142872013 cites W2069910906 @default.
- W142872013 cites W207137709 @default.
- W142872013 cites W2071667691 @default.
- W142872013 cites W2071671121 @default.
- W142872013 cites W2071766779 @default.
- W142872013 cites W2074465151 @default.
- W142872013 cites W2075485887 @default.
- W142872013 cites W2077248637 @default.
- W142872013 cites W2077938696 @default.
- W142872013 cites W2078667380 @default.
- W142872013 cites W2079133863 @default.
- W142872013 cites W2079396472 @default.
- W142872013 cites W2080297087 @default.
- W142872013 cites W2085360023 @default.
- W142872013 cites W2086476168 @default.
- W142872013 cites W2087718777 @default.
- W142872013 cites W2090376401 @default.
- W142872013 cites W2093341571 @default.
- W142872013 cites W2095046735 @default.
- W142872013 cites W2098383030 @default.
- W142872013 cites W2099906854 @default.
- W142872013 cites W2100710603 @default.
- W142872013 cites W2101061562 @default.
- W142872013 cites W2103825144 @default.
- W142872013 cites W2106028065 @default.
- W142872013 cites W2108330676 @default.
- W142872013 cites W2112791998 @default.
- W142872013 cites W2113138439 @default.
- W142872013 cites W2114604545 @default.
- W142872013 cites W2119250965 @default.
- W142872013 cites W2121848782 @default.
- W142872013 cites W2124645509 @default.
- W142872013 cites W2128747139 @default.
- W142872013 cites W2130355366 @default.
- W142872013 cites W2131046811 @default.
- W142872013 cites W2133648811 @default.
- W142872013 cites W2134500795 @default.
- W142872013 cites W2135676423 @default.
- W142872013 cites W2137827663 @default.
- W142872013 cites W2137976895 @default.
- W142872013 cites W2138296165 @default.
- W142872013 cites W2138829545 @default.
- W142872013 cites W2143056053 @default.
- W142872013 cites W2145427481 @default.