Matches in SemOpenAlex for { <https://semopenalex.org/work/W1428953978> ?p ?o ?g. }
- W1428953978 endingPage "183" @default.
- W1428953978 startingPage "167" @default.
- W1428953978 abstract "Towards unraveling the influenza A (H1N1) immunome, this work aims at constructing the murine host response pathway interactome. To accomplish that, an ensemble of dynamic and time-varying Gene Regulatory Network Inference methodologies was recruited to set a confident interactome based on mouse time series transcriptome data (day 1–day 60). The proposed H1N1 interactome demonstrated significant transformations among activated and suppressed pathways in time. Enhanced interplay was observed at day 1, while the maximal network complexity was reached at day 8 (correlated with viral clearance and iBALT tissue formation) and one interaction was present at day 40. Next, we searched for common interactivity features between the murine-adapted PR8 strain and other influenza A subtypes/strains. For this, two other interactomes, describing the murine host response against H5N1 and H1N1pdm, were constructed, which in turn validated many of the observed interactions (in the period day 1–day 7). The H1N1 interactome revealed the role of cell cycle both in innate and adaptive immunity (day 1–day 14). Also, pathogen sensory pathways (e.g., RIG-I) displayed long-lasting association with cytokine/chemokine signaling (until day 8). Interestingly, the above observations were also supported by the H5N1 and H1N1pdm models. It also elucidated the enhanced coupling of the activated innate pathways with the suppressed PPAR signaling to keep low inflammation until viral clearance (until day 14). Further, it showed that interactions reflecting phagocytosis processes continued long after the viral clearance and the establishment of adaptive immunity (day 8–day 40). Additionally, interactions involving B cell receptor pathway were evident since day 1. These results collectively inform the emerging field of public health omics and future clinical studies aimed at deciphering dynamic host responses to infectious agents." @default.
- W1428953978 created "2016-06-24" @default.
- W1428953978 creator A5012058127 @default.
- W1428953978 creator A5020416104 @default.
- W1428953978 creator A5038499176 @default.
- W1428953978 creator A5067553950 @default.
- W1428953978 creator A5077147419 @default.
- W1428953978 creator A5080347335 @default.
- W1428953978 creator A5089495557 @default.
- W1428953978 date "2014-03-01" @default.
- W1428953978 modified "2023-09-23" @default.
- W1428953978 title "Influenza A Immunomics and Public Health Omics: The Dynamic Pathway Interplay in Host Response to H1N1 Infection" @default.
- W1428953978 cites W1500810463 @default.
- W1428953978 cites W1528046055 @default.
- W1428953978 cites W1964305071 @default.
- W1428953978 cites W1970935026 @default.
- W1428953978 cites W1977886386 @default.
- W1428953978 cites W1978334109 @default.
- W1428953978 cites W1989043999 @default.
- W1428953978 cites W1989119979 @default.
- W1428953978 cites W1989708898 @default.
- W1428953978 cites W1989838345 @default.
- W1428953978 cites W1994698160 @default.
- W1428953978 cites W2004445027 @default.
- W1428953978 cites W2014184548 @default.
- W1428953978 cites W2014948594 @default.
- W1428953978 cites W2019920909 @default.
- W1428953978 cites W2025729280 @default.
- W1428953978 cites W2029785503 @default.
- W1428953978 cites W2042282990 @default.
- W1428953978 cites W2070132642 @default.
- W1428953978 cites W2074810866 @default.
- W1428953978 cites W2076372398 @default.
- W1428953978 cites W2081578405 @default.
- W1428953978 cites W2088367672 @default.
- W1428953978 cites W2090209293 @default.
- W1428953978 cites W2096295012 @default.
- W1428953978 cites W2097747115 @default.
- W1428953978 cites W2103215633 @default.
- W1428953978 cites W2106927126 @default.
- W1428953978 cites W2108421561 @default.
- W1428953978 cites W2109384743 @default.
- W1428953978 cites W2109521384 @default.
- W1428953978 cites W2112639149 @default.
- W1428953978 cites W2114172480 @default.
- W1428953978 cites W2114324579 @default.
- W1428953978 cites W2114565252 @default.
- W1428953978 cites W2115108153 @default.
- W1428953978 cites W2117994680 @default.
- W1428953978 cites W2129265801 @default.
- W1428953978 cites W2136988691 @default.
- W1428953978 cites W2138878175 @default.
- W1428953978 cites W2145798475 @default.
- W1428953978 cites W2148663653 @default.
- W1428953978 cites W2153398022 @default.
- W1428953978 cites W2157448920 @default.
- W1428953978 cites W2157898013 @default.
- W1428953978 cites W2158217645 @default.
- W1428953978 cites W2159675211 @default.
- W1428953978 cites W2159777812 @default.
- W1428953978 cites W2160697532 @default.
- W1428953978 cites W2161443380 @default.
- W1428953978 cites W2161467890 @default.
- W1428953978 cites W2162142051 @default.
- W1428953978 cites W2163921837 @default.
- W1428953978 cites W2166106382 @default.
- W1428953978 cites W2166920812 @default.
- W1428953978 cites W2168573378 @default.
- W1428953978 cites W2169336597 @default.
- W1428953978 cites W2169589032 @default.
- W1428953978 cites W2171711783 @default.
- W1428953978 cites W2172218870 @default.
- W1428953978 cites W4241560068 @default.
- W1428953978 doi "https://doi.org/10.1089/omi.2013.0062" @default.
- W1428953978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24512282" @default.
- W1428953978 hasPublicationYear "2014" @default.
- W1428953978 type Work @default.
- W1428953978 sameAs 1428953978 @default.
- W1428953978 citedByCount "12" @default.
- W1428953978 countsByYear W14289539782014 @default.
- W1428953978 countsByYear W14289539782015 @default.
- W1428953978 countsByYear W14289539782016 @default.
- W1428953978 countsByYear W14289539782018 @default.
- W1428953978 countsByYear W14289539782019 @default.
- W1428953978 countsByYear W14289539782020 @default.
- W1428953978 countsByYear W14289539782021 @default.
- W1428953978 countsByYear W14289539782022 @default.
- W1428953978 countsByYear W14289539782023 @default.
- W1428953978 crossrefType "journal-article" @default.
- W1428953978 hasAuthorship W1428953978A5012058127 @default.
- W1428953978 hasAuthorship W1428953978A5020416104 @default.
- W1428953978 hasAuthorship W1428953978A5038499176 @default.
- W1428953978 hasAuthorship W1428953978A5067553950 @default.
- W1428953978 hasAuthorship W1428953978A5077147419 @default.
- W1428953978 hasAuthorship W1428953978A5080347335 @default.
- W1428953978 hasAuthorship W1428953978A5089495557 @default.
- W1428953978 hasConcept C104317684 @default.
- W1428953978 hasConcept C13373296 @default.