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- W1429063551 abstract "This chapter discusses molecular pathogenesis and therapeutic targets in Huntington's disease (HD). HD is an autosomal dominant, late onset neurodegenerative disease that is caused by a CAG/polyglutamine repeat expansion. Individuals with HD usually remain unaffected until midlife, when they manifest the typical motor and emotional symptoms, including chorea, rigidity, bradykinesia, irritability, and chronic depression. Since the cloning of the HD gene in 1993, great progress has been made in understanding its molecular pathogenesis and uncovering potential therapeutic targets. In addition, a wide range of excellent genetic models has been generated that include yeast, C. elegans, D. melanogaster, mammalian cell culture models, mice, and rats. These are being used to further unravel and validate the mechanisms by which cellular function becomes disrupted in HD and to develop a drug discovery pipeline through which promising drugs can be tested in a variety of genetic systems. This will enable the translation of basic research into the clinic and hopefully the eventual development of an effective treatment or cure for HD. © 2006 Elsevier Inc." @default.
- W1429063551 created "2016-06-24" @default.
- W1429063551 creator A5020296130 @default.
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- W1429063551 date "2006-01-01" @default.
- W1429063551 modified "2023-10-14" @default.
- W1429063551 title "Molecular Pathogenesis and Therapeutic Targets in Huntington's Disease" @default.
- W1429063551 cites W123307853 @default.
- W1429063551 cites W1481321944 @default.
- W1429063551 cites W1485896673 @default.
- W1429063551 cites W1486617476 @default.
- W1429063551 cites W1509701720 @default.
- W1429063551 cites W1511237419 @default.
- W1429063551 cites W1523616760 @default.
- W1429063551 cites W1529494566 @default.
- W1429063551 cites W1531415074 @default.
- W1429063551 cites W1532930401 @default.
- W1429063551 cites W1541950149 @default.
- W1429063551 cites W1563847798 @default.
- W1429063551 cites W1579287598 @default.
- W1429063551 cites W1579354139 @default.
- W1429063551 cites W1582551464 @default.
- W1429063551 cites W1584816388 @default.
- W1429063551 cites W1606672690 @default.
- W1429063551 cites W1639255528 @default.
- W1429063551 cites W1643390591 @default.
- W1429063551 cites W1750171938 @default.
- W1429063551 cites W1797863618 @default.
- W1429063551 cites W1892455234 @default.
- W1429063551 cites W1949056714 @default.
- W1429063551 cites W1954166865 @default.
- W1429063551 cites W1964372470 @default.
- W1429063551 cites W1965285716 @default.
- W1429063551 cites W1967141382 @default.
- W1429063551 cites W1972251644 @default.
- W1429063551 cites W1973191842 @default.
- W1429063551 cites W1977383752 @default.
- W1429063551 cites W1977733590 @default.
- W1429063551 cites W1979999423 @default.
- W1429063551 cites W1980636359 @default.
- W1429063551 cites W1982138681 @default.
- W1429063551 cites W1982623268 @default.
- W1429063551 cites W1984322190 @default.
- W1429063551 cites W1984332363 @default.
- W1429063551 cites W1985474993 @default.
- W1429063551 cites W1985963540 @default.
- W1429063551 cites W1988146888 @default.
- W1429063551 cites W1988219126 @default.
- W1429063551 cites W1991354828 @default.
- W1429063551 cites W1992341804 @default.
- W1429063551 cites W1992921611 @default.
- W1429063551 cites W1995188451 @default.
- W1429063551 cites W1996242123 @default.
- W1429063551 cites W1996789718 @default.
- W1429063551 cites W1997369314 @default.
- W1429063551 cites W1997555550 @default.
- W1429063551 cites W1997883336 @default.
- W1429063551 cites W1997887740 @default.
- W1429063551 cites W1999267642 @default.
- W1429063551 cites W2000640243 @default.
- W1429063551 cites W2002431899 @default.
- W1429063551 cites W2002644780 @default.
- W1429063551 cites W2002763309 @default.
- W1429063551 cites W2004969253 @default.
- W1429063551 cites W2005927762 @default.
- W1429063551 cites W2007719003 @default.
- W1429063551 cites W2007945544 @default.
- W1429063551 cites W2008773550 @default.
- W1429063551 cites W2009568691 @default.
- W1429063551 cites W2014311428 @default.
- W1429063551 cites W2014520750 @default.
- W1429063551 cites W2015241097 @default.
- W1429063551 cites W2017492499 @default.
- W1429063551 cites W2017645644 @default.
- W1429063551 cites W2018928754 @default.
- W1429063551 cites W2021388992 @default.
- W1429063551 cites W2021551531 @default.
- W1429063551 cites W2022372660 @default.
- W1429063551 cites W2022851867 @default.
- W1429063551 cites W2023218749 @default.
- W1429063551 cites W2024570377 @default.
- W1429063551 cites W2026124745 @default.
- W1429063551 cites W2030575711 @default.
- W1429063551 cites W2032255653 @default.
- W1429063551 cites W2032603387 @default.
- W1429063551 cites W2033325995 @default.
- W1429063551 cites W2040671431 @default.
- W1429063551 cites W2041993377 @default.
- W1429063551 cites W2042716629 @default.
- W1429063551 cites W2042739691 @default.
- W1429063551 cites W2043762704 @default.
- W1429063551 cites W2043899474 @default.
- W1429063551 cites W2044564243 @default.
- W1429063551 cites W2045023032 @default.
- W1429063551 cites W2045056620 @default.
- W1429063551 cites W2046979739 @default.
- W1429063551 cites W2047638794 @default.
- W1429063551 cites W2050589769 @default.
- W1429063551 cites W2057091932 @default.