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- W142953402 abstract "Publisher Summary Isofloxythepin is a new oral neuroleptic drug with long-acting action. This chapter discusses a study for the development of supersensitive state on dopaminergic receptors after the acute administration of neuroleptic drug isofloxythepin. The effect of isofloxythepin on dopaminergic system in rats was found biphasic. In short intervals (24 and 48 h after the administration), striatal HVA and DOPAC were increased and apomorphine stereotypy was counteracted. On the contrary, in long intervals (4–6 days), both DA metabolites were decreased significantly below the control values and apomorphine stereotypy was enhanced. The influence of isofloxythepin on prolactin secretion, its interaction with apomorphine on striatal HVA, and repeated administration of isofloxythepin were compared in short and long intervals. The stereospecifity of isofloxythepin action was also demonstrated. The observed delayed reversion of dopaminergic transmission after isofloxythepin might be explained by the development of supersensitivity state on dopaminergic receptors." @default.
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- W142953402 date "1980-01-01" @default.
- W142953402 modified "2023-09-27" @default.
- W142953402 title "DEVELOPMENT OF SUPERSENSITIVE STATE ON DOPAMINERGIC RECEPTORS AFTER THE ACUTE ADMINISTRATION OF NEUROLEPTIC DRUG ISOFLOXYTHEPIN" @default.
- W142953402 doi "https://doi.org/10.1016/b978-0-08-025921-5.50069-2" @default.
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