Matches in SemOpenAlex for { <https://semopenalex.org/work/W14304059> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W14304059 abstract "Collagen XXIV, discovered as a cDNA, has a typical C-propeptide domain, indicating the molecule is a member of the fibrillar collagens. The amino terminal non-collagenous domain is large, similar to those of fibrillar collagen alpha1(V), alpha1(XI) and alpha1(XI) chains. The triple helical domain is about 100 amino acids shorter than other fibrillar collagen chains and contains an imperfection (Koch et al., JBC 278: 43236, 2003). The gene is activated late in the osteoblast differentiation program, and is regulated by CREB-AP1 (Matsuo et al., JBC 281:5445, 2006; Matsuo et al., Conn Tiss Res 49:68, 2008). Our objective was to evaluate the importance of collagen XXIV to the architecture of bone by examining null mice. MicroCT analysis of the femurs of 5 month old null mice were compared with those of age matched wild type mice. The cortical bone was less dense in the null mice and cross sections through the distal femur displayed fewer trabeculae. 3D reconstructions indicated that the femurs of the null mice had the same bone volume as the wild type femurs, but that the bone was less dense, having an osteoporotic appearance. Conclusion: Collagen XXIV is important for proper bone density." @default.
- W14304059 created "2016-06-24" @default.
- W14304059 creator A5007618719 @default.
- W14304059 creator A5052231842 @default.
- W14304059 creator A5067941504 @default.
- W14304059 creator A5089751683 @default.
- W14304059 creator A5091510217 @default.
- W14304059 date "2010-04-01" @default.
- W14304059 modified "2023-09-23" @default.
- W14304059 title "Collagen XXIV null mice have osteoporotic bones" @default.
- W14304059 doi "https://doi.org/10.1096/fasebj.24.1_supplement.638.1" @default.
- W14304059 hasPublicationYear "2010" @default.
- W14304059 type Work @default.
- W14304059 sameAs 14304059 @default.
- W14304059 citedByCount "0" @default.
- W14304059 crossrefType "journal-article" @default.
- W14304059 hasAuthorship W14304059A5007618719 @default.
- W14304059 hasAuthorship W14304059A5052231842 @default.
- W14304059 hasAuthorship W14304059A5067941504 @default.
- W14304059 hasAuthorship W14304059A5089751683 @default.
- W14304059 hasAuthorship W14304059A5091510217 @default.
- W14304059 hasConcept C124101348 @default.
- W14304059 hasConcept C126322002 @default.
- W14304059 hasConcept C199343813 @default.
- W14304059 hasConcept C203763787 @default.
- W14304059 hasConcept C41008148 @default.
- W14304059 hasConcept C71924100 @default.
- W14304059 hasConceptScore W14304059C124101348 @default.
- W14304059 hasConceptScore W14304059C126322002 @default.
- W14304059 hasConceptScore W14304059C199343813 @default.
- W14304059 hasConceptScore W14304059C203763787 @default.
- W14304059 hasConceptScore W14304059C41008148 @default.
- W14304059 hasConceptScore W14304059C71924100 @default.
- W14304059 hasIssue "S1" @default.
- W14304059 hasLocation W143040591 @default.
- W14304059 hasOpenAccess W14304059 @default.
- W14304059 hasPrimaryLocation W143040591 @default.
- W14304059 hasRelatedWork W1531899892 @default.
- W14304059 hasRelatedWork W1994734785 @default.
- W14304059 hasRelatedWork W2024808467 @default.
- W14304059 hasRelatedWork W2031230476 @default.
- W14304059 hasRelatedWork W2039694093 @default.
- W14304059 hasRelatedWork W2043033796 @default.
- W14304059 hasRelatedWork W2078583536 @default.
- W14304059 hasRelatedWork W2091365791 @default.
- W14304059 hasRelatedWork W2118918909 @default.
- W14304059 hasRelatedWork W2134410148 @default.
- W14304059 hasRelatedWork W2136493671 @default.
- W14304059 hasRelatedWork W213743310 @default.
- W14304059 hasRelatedWork W2290752975 @default.
- W14304059 hasRelatedWork W2306436066 @default.
- W14304059 hasVolume "24" @default.
- W14304059 isParatext "false" @default.
- W14304059 isRetracted "false" @default.
- W14304059 magId "14304059" @default.
- W14304059 workType "article" @default.