Matches in SemOpenAlex for { <https://semopenalex.org/work/W143089491> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W143089491 endingPage "62" @default.
- W143089491 startingPage "3758" @default.
- W143089491 abstract "In a prospective study of thirty five consecutive patients with decreased plasma cobalamine (P-Cbl), twenty-two (63%) were diagnosed as having pernicious anaemia (PA) (no age or sex differences) on basis of the B12-absorption test and/or megaloblastic changes in the bone marrow. In this group ten patients were anaemic (six of whom were characterized as macrocytic), sixteen of nineteen examined had megaloblastic changes in the bone marrow, and all of thirteen examined had achlorhydria with positive correlation to Parietal Cell Antibodies (PCA). Two patients with PA had normal Cbl-absorption and two had malabsorption at the time of diagnosis. Twenty-one patients (95%) had PCA and thirteen (59%) were Intrinsic Factor Antibody (IFAb) positive. Three patients IFAb-seroconverted within a year. Among the remaining thirteen patients (37%), one had PCA but not IFAb and three were IFAb-positive all of whom had normal Cbl-absorption. Of the three patients with IFAb one had also PCA, one IFAb-seroconverted within three months, and one had microcytic anaemia with iron depleted bone marrow due to coecal cancer. Among twenty two healthy adult controls four (18%) had PCA while none had IFAb. This investigation shows that at the debut half of PA patients (55%) do not have anaemia, some have normal Cbl-absorption and some have malabsorption. 95% have PCA and 59% have IFAb. So, IFAb-negative PA is often seen (41%) and seroconversion can take place. Diagnosis is even more reliable, when achlorhydria is present in PCA-positive persons. Healthy PCA-positive persons are probably predisposed to develop PA. Patients with cbl-deficiency, IFAb and/or PCA must be considered as having latent PA even if they have normal haemoglobin and normal Cbl-absorption. These patients should be followed and, in case of anaemia or signs of neuropathia, treated.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W143089491 created "2016-06-24" @default.
- W143089491 creator A5001719061 @default.
- W143089491 creator A5010317804 @default.
- W143089491 creator A5029223721 @default.
- W143089491 creator A5085122960 @default.
- W143089491 creator A5091464285 @default.
- W143089491 date "1992-12-21" @default.
- W143089491 modified "2023-09-25" @default.
- W143089491 title "[Pernicious anemia. A study of initial forms of the disease and diagnostic significance of determination of the intrinsic factor antibody and parietal cell antibody]." @default.
- W143089491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1471305" @default.
- W143089491 hasPublicationYear "1992" @default.
- W143089491 type Work @default.
- W143089491 sameAs 143089491 @default.
- W143089491 citedByCount "5" @default.
- W143089491 countsByYear W1430894912013 @default.
- W143089491 countsByYear W1430894912014 @default.
- W143089491 countsByYear W1430894912017 @default.
- W143089491 countsByYear W1430894912022 @default.
- W143089491 crossrefType "journal-article" @default.
- W143089491 hasAuthorship W143089491A5001719061 @default.
- W143089491 hasAuthorship W143089491A5010317804 @default.
- W143089491 hasAuthorship W143089491A5029223721 @default.
- W143089491 hasAuthorship W143089491A5085122960 @default.
- W143089491 hasAuthorship W143089491A5091464285 @default.
- W143089491 hasConcept C126322002 @default.
- W143089491 hasConcept C159654299 @default.
- W143089491 hasConcept C203014093 @default.
- W143089491 hasConcept C2775916456 @default.
- W143089491 hasConcept C2777569460 @default.
- W143089491 hasConcept C2778248108 @default.
- W143089491 hasConcept C2779405478 @default.
- W143089491 hasConcept C2779422922 @default.
- W143089491 hasConcept C2779750884 @default.
- W143089491 hasConcept C2779970781 @default.
- W143089491 hasConcept C2780439177 @default.
- W143089491 hasConcept C71924100 @default.
- W143089491 hasConcept C90924648 @default.
- W143089491 hasConceptScore W143089491C126322002 @default.
- W143089491 hasConceptScore W143089491C159654299 @default.
- W143089491 hasConceptScore W143089491C203014093 @default.
- W143089491 hasConceptScore W143089491C2775916456 @default.
- W143089491 hasConceptScore W143089491C2777569460 @default.
- W143089491 hasConceptScore W143089491C2778248108 @default.
- W143089491 hasConceptScore W143089491C2779405478 @default.
- W143089491 hasConceptScore W143089491C2779422922 @default.
- W143089491 hasConceptScore W143089491C2779750884 @default.
- W143089491 hasConceptScore W143089491C2779970781 @default.
- W143089491 hasConceptScore W143089491C2780439177 @default.
- W143089491 hasConceptScore W143089491C71924100 @default.
- W143089491 hasConceptScore W143089491C90924648 @default.
- W143089491 hasIssue "52" @default.
- W143089491 hasLocation W1430894911 @default.
- W143089491 hasOpenAccess W143089491 @default.
- W143089491 hasPrimaryLocation W1430894911 @default.
- W143089491 hasRelatedWork W1549107604 @default.
- W143089491 hasRelatedWork W1968740123 @default.
- W143089491 hasRelatedWork W1986702094 @default.
- W143089491 hasRelatedWork W2018623392 @default.
- W143089491 hasRelatedWork W2021758558 @default.
- W143089491 hasRelatedWork W2030946615 @default.
- W143089491 hasRelatedWork W2067508148 @default.
- W143089491 hasRelatedWork W2132028204 @default.
- W143089491 hasRelatedWork W2464809676 @default.
- W143089491 hasRelatedWork W73133096 @default.
- W143089491 hasVolume "154" @default.
- W143089491 isParatext "false" @default.
- W143089491 isRetracted "false" @default.
- W143089491 magId "143089491" @default.
- W143089491 workType "article" @default.