FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1431191500> ?p ?o ?g. }

• W1431191500 endingPage "6" @default.
• W1431191500 startingPage "1" @default.
• W1431191500 abstract "Direct manipulations of neuronal activity have been shown to induce changes in DNA methylation (DNAm), although little is known about the cellular signaling pathways involved. Using reduced representation bisulfite sequencing, we identify DNAm changes associated with moderate chronic depolarization in dissociated rat hippocampal cultures. Consistent with previous findings, these changes occurred primarily in the vicinity of loci implicated in neuronal function, being enriched in intergenic regions and underrepresented in CpG-rich promoter regulatory regions. We subsequently used 2 pharmacological interventions (nifedipine and FK-506) to test whether the identified changes depended on 2 interrelated signaling pathways known to mediate multiple forms of neuronal plasticity. Both pharmacological manipulations had notable effects on the extent and magnitude of depolarization-induced DNAm changes indicating that a high proportion of activity-induced changes are likely to be mediated by calcium entry through L-type CaV1 channels and/or downstream signaling via the calcium-dependent phosphatase calcineurin." @default.
• W1431191500 created "2016-06-24" @default.
• W1431191500 creator A5018092286 @default.
• W1431191500 creator A5022493276 @default.
• W1431191500 creator A5032640130 @default.
• W1431191500 creator A5047455423 @default.
• W1431191500 creator A5049350976 @default.
• W1431191500 creator A5061089999 @default.
• W1431191500 date "2015-07-01" @default.
• W1431191500 modified "2023-10-18" @default.
• W1431191500 title "A role for CaV1 and calcineurin signaling in depolarization-induced changes in neuronal DNA methylation" @default.
• W1431191500 cites W1506631602 @default.
• W1431191500 cites W1980511338 @default.
• W1431191500 cites W1989092549 @default.
• W1431191500 cites W1991244004 @default.
• W1431191500 cites W1994872818 @default.
• W1431191500 cites W1995218600 @default.
• W1431191500 cites W2018419725 @default.
• W1431191500 cites W2021738239 @default.
• W1431191500 cites W2026255880 @default.
• W1431191500 cites W2028474009 @default.
• W1431191500 cites W2032882684 @default.
• W1431191500 cites W2033606638 @default.
• W1431191500 cites W2041597075 @default.
• W1431191500 cites W2047246007 @default.
• W1431191500 cites W2053309035 @default.
• W1431191500 cites W2062579993 @default.
• W1431191500 cites W2062830599 @default.
• W1431191500 cites W2062872787 @default.
• W1431191500 cites W2064226140 @default.
• W1431191500 cites W2064756496 @default.
• W1431191500 cites W2064899241 @default.
• W1431191500 cites W2067004457 @default.
• W1431191500 cites W2071957609 @default.
• W1431191500 cites W2074750860 @default.
• W1431191500 cites W2076236349 @default.
• W1431191500 cites W2082338288 @default.
• W1431191500 cites W2092765329 @default.
• W1431191500 cites W2101567225 @default.
• W1431191500 cites W2102256305 @default.
• W1431191500 cites W2102573876 @default.
• W1431191500 cites W2106976893 @default.
• W1431191500 cites W2109104859 @default.
• W1431191500 cites W2109807917 @default.
• W1431191500 cites W2115818350 @default.
• W1431191500 cites W2120629185 @default.
• W1431191500 cites W2121090755 @default.
• W1431191500 cites W2131374955 @default.
• W1431191500 cites W2148337554 @default.
• W1431191500 cites W2151942667 @default.
• W1431191500 cites W2152642144 @default.
• W1431191500 cites W2153122353 @default.
• W1431191500 cites W2153438315 @default.
• W1431191500 cites W2158256695 @default.
• W1431191500 cites W2170067815 @default.
• W1431191500 cites W2170760271 @default.
• W1431191500 doi "https://doi.org/10.1016/j.nepig.2015.06.001" @default.
• W1431191500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4659419" @default.
• W1431191500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26702400" @default.
• W1431191500 hasPublicationYear "2015" @default.
• W1431191500 type Work @default.
• W1431191500 sameAs 1431191500 @default.
• W1431191500 citedByCount "5" @default.
• W1431191500 countsByYear W14311915002016 @default.
• W1431191500 countsByYear W14311915002018 @default.
• W1431191500 countsByYear W14311915002021 @default.
• W1431191500 countsByYear W14311915002022 @default.
• W1431191500 crossrefType "journal-article" @default.
• W1431191500 hasAuthorship W1431191500A5018092286 @default.
• W1431191500 hasAuthorship W1431191500A5022493276 @default.
• W1431191500 hasAuthorship W1431191500A5032640130 @default.
• W1431191500 hasAuthorship W1431191500A5047455423 @default.
• W1431191500 hasAuthorship W1431191500A5049350976 @default.
• W1431191500 hasAuthorship W1431191500A5061089999 @default.
• W1431191500 hasBestOaLocation W14311915001 @default.
• W1431191500 hasConcept C104317684 @default.
• W1431191500 hasConcept C126322002 @default.
• W1431191500 hasConcept C128057223 @default.
• W1431191500 hasConcept C134018914 @default.
• W1431191500 hasConcept C140173407 @default.
• W1431191500 hasConcept C148762608 @default.
• W1431191500 hasConcept C150194340 @default.
• W1431191500 hasConcept C169760540 @default.
• W1431191500 hasConcept C190727270 @default.
• W1431191500 hasConcept C201571599 @default.
• W1431191500 hasConcept C2775921022 @default.
• W1431191500 hasConcept C2911091166 @default.
• W1431191500 hasConcept C4141045 @default.
• W1431191500 hasConcept C54355233 @default.
• W1431191500 hasConcept C62478195 @default.
• W1431191500 hasConcept C71924100 @default.
• W1431191500 hasConcept C74254510 @default.
• W1431191500 hasConcept C86803240 @default.
• W1431191500 hasConcept C95444343 @default.
• W1431191500 hasConceptScore W1431191500C104317684 @default.
• W1431191500 hasConceptScore W1431191500C126322002 @default.
• W1431191500 hasConceptScore W1431191500C128057223 @default.
• W1431191500 hasConceptScore W1431191500C134018914 @default.

• next