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- W143230082 abstract "Acute administration of atypical antipsychotic drugs, such as clozapine, produces an increase in the efflux of catecholamines preferentially in the prefrontal cortex (PFC) and a characteristic expression of Fos-like immunoreactivity (Fos-li) in the forebrain of experimental animals. We examined the effects of the CB-1 receptor antagonist rimonabant on clozapine-induced increases in the efflux of dopamine (DA) and norepinephrine (NE) in the PFC, and Fos-li in the PFC, nucleus accumbens shell (NAc-shell) and core (NAc-core) and dorsolateral striatum (DL-Str) in the rat. Rimonabant and clozapine dose-dependently increased cortical efflux of DA and NE. Pretreatment (30min) with rimonabant (3mg/kg, IP) significantly enhanced the clozapine (10mg/kg, SC)-induced increase in catecholamine efflux in the PFC. Clozapine (8mg/kg, SC) significantly increased the Fos-li in the PFC and NAc-shell. Rimonabant (10mg/kg, IP) significantly increased the Fos-li in the PFC. Rimonabant pretreatment (30min) significantly enhanced the clozapine-induced Fos-li in the PFC and NAc-shell. Clozapine alone and the combination of rimonabant and clozapine demonstrated a positive atypical index (based on the difference in the Fos-li in the NAc-shell versus the DL-Str) indicating atypicality of antipsychotic-like activity. The present results indicate that rimonabant enhances the neurochemical and histochemical effects of clozapine and that this combined administration reveals an atypical antipsychotic-like profile of drug action. Funded by: Eli Lilly and Co." @default.
- W143230082 created "2016-06-24" @default.
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- W143230082 date "2006-03-01" @default.
- W143230082 modified "2023-09-27" @default.
- W143230082 title "Rimonabant enhances clozapine‐induced neurochemical and histochemical responses in the rat" @default.
- W143230082 doi "https://doi.org/10.1096/fasebj.20.5.lb114-a" @default.
- W143230082 hasPublicationYear "2006" @default.
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