FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1433111841> ?p ?o ?g. }

• W1433111841 endingPage "101" @default.
• W1433111841 startingPage "101" @default.
• W1433111841 abstract "Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery Jae Yeon Joo, GilYong Park, SeongSoo A An Department of Bionano Technology, Gachon Medical Research Institute, Gachon University, Seongnam-si, Republic of Korea Abstract: In the development of effective drug delivery carriers, many researchers have focused on the usage of nontoxic and biocompatible materials and surface modification with targeting molecules for tumor-specific drug delivery. Fibrinogen (Fbg), an abundant glycoprotein in plasma, could be a potential candidate for developing drug carriers because of its biocompatibility and tumor-targeting property via arginine–glycine–aspartate (RGD) peptide sequences. Doxorubicin (DOX), a chemotherapeutic agent, was covalently conjugated to Fbg, and the microspheres were prepared. Acid-labile and non-cleavable linkers were used for the conjugation of DOX to Fbg, resulting in an acid-triggered drug release under a mild acidic condition and a slow-controlled drug release, respectively. In vitro cytotoxicity tests confirmed low cytotoxicity in normal cells and high antitumor effect toward cancer cells. In addition, it was discovered that a longer linker could make the binding of cells to Fbg drug carriers easier. Therefore, DOX–linker–Fbg microspheres could be a suitable drug carrier for safer and effective drug delivery. Keywords: biocompatibility, anti-cancer drug, micro-structure, cytotoxicity, bio-conjugation, tumor targeting" @default.
• W1433111841 created "2016-06-24" @default.
• W1433111841 creator A5013951360 @default.
• W1433111841 creator A5014297807 @default.
• W1433111841 creator A5049571369 @default.
• W1433111841 date "2015-09-01" @default.
• W1433111841 modified "2023-09-25" @default.
• W1433111841 title "Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery" @default.
• W1433111841 cites W1900516866 @default.
• W1433111841 cites W1965706412 @default.
• W1433111841 cites W1967833812 @default.
• W1433111841 cites W1973008499 @default.
• W1433111841 cites W1982500127 @default.
• W1433111841 cites W1983288921 @default.
• W1433111841 cites W1996585845 @default.
• W1433111841 cites W2016750917 @default.
• W1433111841 cites W2032222317 @default.
• W1433111841 cites W2033281188 @default.
• W1433111841 cites W2044290311 @default.
• W1433111841 cites W2048313558 @default.
• W1433111841 cites W2054334269 @default.
• W1433111841 cites W2055000650 @default.
• W1433111841 cites W2060451360 @default.
• W1433111841 cites W2069733099 @default.
• W1433111841 cites W2076244380 @default.
• W1433111841 cites W2078579517 @default.
• W1433111841 cites W2086488119 @default.
• W1433111841 cites W2112636933 @default.
• W1433111841 cites W2118072247 @default.
• W1433111841 cites W2131130373 @default.
• W1433111841 cites W2138003976 @default.
• W1433111841 cites W2142580186 @default.
• W1433111841 cites W2159306777 @default.
• W1433111841 cites W2167891614 @default.
• W1433111841 cites W2313437616 @default.
• W1433111841 doi "https://doi.org/10.2147/ijn.s88381" @default.
• W1433111841 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4562758" @default.
• W1433111841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26366073" @default.
• W1433111841 hasPublicationYear "2015" @default.
• W1433111841 type Work @default.
• W1433111841 sameAs 1433111841 @default.
• W1433111841 citedByCount "4" @default.
• W1433111841 countsByYear W14331118412017 @default.
• W1433111841 countsByYear W14331118412019 @default.
• W1433111841 countsByYear W14331118412021 @default.
• W1433111841 countsByYear W14331118412023 @default.
• W1433111841 crossrefType "journal-article" @default.
• W1433111841 hasAuthorship W1433111841A5013951360 @default.
• W1433111841 hasAuthorship W1433111841A5014297807 @default.
• W1433111841 hasAuthorship W1433111841A5049571369 @default.
• W1433111841 hasBestOaLocation W14331118411 @default.
• W1433111841 hasConcept C109316439 @default.
• W1433111841 hasConcept C111919701 @default.
• W1433111841 hasConcept C121608353 @default.
• W1433111841 hasConcept C126322002 @default.
• W1433111841 hasConcept C126511603 @default.
• W1433111841 hasConcept C13245373 @default.
• W1433111841 hasConcept C141071460 @default.
• W1433111841 hasConcept C171250308 @default.
• W1433111841 hasConcept C178790620 @default.
• W1433111841 hasConcept C185592680 @default.
• W1433111841 hasConcept C192562407 @default.
• W1433111841 hasConcept C202751555 @default.
• W1433111841 hasConcept C2776694085 @default.
• W1433111841 hasConcept C2777230088 @default.
• W1433111841 hasConcept C2779820397 @default.
• W1433111841 hasConcept C2780035454 @default.
• W1433111841 hasConcept C2780557392 @default.
• W1433111841 hasConcept C2781303535 @default.
• W1433111841 hasConcept C41008148 @default.
• W1433111841 hasConcept C55493867 @default.
• W1433111841 hasConcept C71924100 @default.
• W1433111841 hasConcept C96232424 @default.
• W1433111841 hasConcept C98274493 @default.
• W1433111841 hasConceptScore W1433111841C109316439 @default.
• W1433111841 hasConceptScore W1433111841C111919701 @default.
• W1433111841 hasConceptScore W1433111841C121608353 @default.
• W1433111841 hasConceptScore W1433111841C126322002 @default.
• W1433111841 hasConceptScore W1433111841C126511603 @default.
• W1433111841 hasConceptScore W1433111841C13245373 @default.
• W1433111841 hasConceptScore W1433111841C141071460 @default.
• W1433111841 hasConceptScore W1433111841C171250308 @default.
• W1433111841 hasConceptScore W1433111841C178790620 @default.
• W1433111841 hasConceptScore W1433111841C185592680 @default.
• W1433111841 hasConceptScore W1433111841C192562407 @default.
• W1433111841 hasConceptScore W1433111841C202751555 @default.
• W1433111841 hasConceptScore W1433111841C2776694085 @default.
• W1433111841 hasConceptScore W1433111841C2777230088 @default.
• W1433111841 hasConceptScore W1433111841C2779820397 @default.
• W1433111841 hasConceptScore W1433111841C2780035454 @default.
• W1433111841 hasConceptScore W1433111841C2780557392 @default.
• W1433111841 hasConceptScore W1433111841C2781303535 @default.
• W1433111841 hasConceptScore W1433111841C41008148 @default.
• W1433111841 hasConceptScore W1433111841C55493867 @default.
• W1433111841 hasConceptScore W1433111841C71924100 @default.
• W1433111841 hasConceptScore W1433111841C96232424 @default.
• W1433111841 hasConceptScore W1433111841C98274493 @default.
• W1433111841 hasLocation W14331118411 @default.

• next