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• W143312188 startingPage "117" @default.
• W143312188 abstract "The main motor symptoms of Parkinson’s disease (PD) are linked to degeneration of the nigrostriatal dopamine (DA) fibers, especially those innervating the putamen. This degeneration can be assessed in molecular imaging studies with presynaptic tracers such as [18F]-fluoro-L-DOPA (FDOPA) and ligands for DA transporter ligands. However, the pathologies of PD are by no means limited to nigrostriatal loss. Results of post mortem and molecular imaging studies reveal parallel degenerations of cortical noradrenaline (NA) and serotonin (5-HT) innervations, which may contribute to affective and cognitive changes of PD. Especially in advanced PD, cognitive impairment can come to resemble that seen in Alzheimer’s dementia, as can the degeneration of acetylcholine innervations arising in the basal forebrain. The density of striatal DA D2 receptors increases in early untreated PD, consistent with denervation upregulation, but there is an accelerated rate of DA receptor loss as the disease advances. Animal studies and post mortem investigations reveal changes in brain opioid peptide systems, but these are poorly documented in imaging studies of PD. Relatively minor changes in the binding sites for GABA are reported in cortex and striatum of PD patients. There remains some controversy about the expression of the 18 kDa translocator protein (TSPO) in activated microglia as an indicator of an active inflammatory component of neurodegeneration in PD. A wide variety of autonomic disturbances contribute to the clinical syndrome of PD; the degeneration of myocardial sympathetic innervation can be revealed in SPECT studies of PD patients with autonomic failure. Considerable emphasis has been placed on investigations of cerebral blood flow and energy metabolism in PD. Due to the high variance of these physiological estimates, researchers have often employed normalization procedures for the sensitive detection of perturbations in relatively small patient groups. However, a widely used normalization to the global mean must be used with caution, as it can result in spurious findings of relative hypermetabolic changes in subcortical structures. A meta-analysis of the quantitative studies to date shows that there is in fact widespread hypometabolism and cerebral blood flow in the cerebral cortex, especially in frontal cortex and parietal association areas. These changes can bias the use of global mean normalization, and probably represent the pathophysiological basis of the cognitive impairment of PD." @default.
• W143312188 created "2016-06-24" @default.
• W143312188 creator A5005853815 @default.
• W143312188 creator A5044995419 @default.
• W143312188 date "2011-01-01" @default.
• W143312188 modified "2023-09-27" @default.
• W143312188 title "Molecular Imaging and the Neuropathologies of Parkinson’s Disease" @default.
• W143312188 cites W1519868135 @default.
• W143312188 cites W1768450208 @default.
• W143312188 cites W1963933632 @default.
• W143312188 cites W1964006251 @default.
• W143312188 cites W1965607993 @default.
• W143312188 cites W1965860594 @default.
• W143312188 cites W1967207691 @default.
• W143312188 cites W1967277729 @default.
• W143312188 cites W1967841007 @default.
• W143312188 cites W1970360769 @default.
• W143312188 cites W1970540862 @default.
• W143312188 cites W1972781961 @default.
• W143312188 cites W1974504043 @default.
• W143312188 cites W1977293177 @default.
• W143312188 cites W1978776771 @default.
• W143312188 cites W1981178008 @default.
• W143312188 cites W1981799390 @default.
• W143312188 cites W1983823130 @default.
• W143312188 cites W1984294537 @default.
• W143312188 cites W1985156573 @default.
• W143312188 cites W1985659221 @default.
• W143312188 cites W1986295871 @default.
• W143312188 cites W1986776141 @default.
• W143312188 cites W1988235609 @default.
• W143312188 cites W1989490147 @default.
• W143312188 cites W1990019125 @default.
• W143312188 cites W1990435051 @default.
• W143312188 cites W1990965418 @default.
• W143312188 cites W1991354131 @default.
• W143312188 cites W1992671089 @default.
• W143312188 cites W1993389023 @default.
• W143312188 cites W1994249908 @default.
• W143312188 cites W1995775753 @default.
• W143312188 cites W1996344789 @default.
• W143312188 cites W1996474930 @default.
• W143312188 cites W1997081993 @default.
• W143312188 cites W1997124326 @default.
• W143312188 cites W1997386708 @default.
• W143312188 cites W1999694937 @default.
• W143312188 cites W2000120626 @default.
• W143312188 cites W2000645624 @default.
• W143312188 cites W2002748828 @default.
• W143312188 cites W2002908024 @default.
• W143312188 cites W2002945837 @default.
• W143312188 cites W2003119385 @default.
• W143312188 cites W2003326996 @default.
• W143312188 cites W2003479107 @default.
• W143312188 cites W2003487039 @default.
• W143312188 cites W2004611188 @default.
• W143312188 cites W2005507422 @default.
• W143312188 cites W2007222385 @default.
• W143312188 cites W2007528040 @default.
• W143312188 cites W2008864191 @default.
• W143312188 cites W2008929322 @default.
• W143312188 cites W2012392954 @default.
• W143312188 cites W2012445753 @default.
• W143312188 cites W2012556157 @default.
• W143312188 cites W2012591195 @default.
• W143312188 cites W2013727579 @default.
• W143312188 cites W2014514861 @default.
• W143312188 cites W2014831739 @default.
• W143312188 cites W2015435658 @default.
• W143312188 cites W2017463010 @default.
• W143312188 cites W2021280501 @default.
• W143312188 cites W2021356347 @default.
• W143312188 cites W2022916785 @default.
• W143312188 cites W2027340686 @default.
• W143312188 cites W2028194176 @default.
• W143312188 cites W2031135445 @default.
• W143312188 cites W2031247327 @default.
• W143312188 cites W2032190306 @default.
• W143312188 cites W2032370847 @default.
• W143312188 cites W2032917483 @default.
• W143312188 cites W2034548134 @default.
• W143312188 cites W2035888448 @default.
• W143312188 cites W2037741322 @default.
• W143312188 cites W2037933006 @default.
• W143312188 cites W2039196632 @default.
• W143312188 cites W2040451117 @default.
• W143312188 cites W2041451038 @default.
• W143312188 cites W2042394906 @default.
• W143312188 cites W2042422091 @default.
• W143312188 cites W2042489157 @default.
• W143312188 cites W2044034572 @default.
• W143312188 cites W2044580180 @default.
• W143312188 cites W2045416175 @default.
• W143312188 cites W2046164046 @default.
• W143312188 cites W2046425761 @default.
• W143312188 cites W2046893885 @default.
• W143312188 cites W2048645115 @default.
• W143312188 cites W2051256200 @default.

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