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- W1433184109 abstract "We studied on the lipid and lipoprotein fractions in sera of myocardial infarction (MI), angina pectoris (AP) and control groups, using routine chemical methods, agarose gel (AGE) and polyacrylamide gel (PGE) electrophoresis and ultracentrifugation. While serum total cholesterol were almost equal among these three groups, the concentration of free cholesterol, triglycerides, total phospholipids, total lipids and free fatty acids were higher, though statistically not significant, in the AP and MI groups than in control one. The percent concentration of β, and the ratios of β/α, pre-β+β/α increased significantly in the AP and MI groups. So-called extra pre-β lipoprotein (ELp) were seen in 18% cases of atherosclerotic diseases (AS) by the method of AGE, while 52% in AS, 38% in hypertension and 25% in controls by the method of PGE. ELp appeared and disappeared in the same individuals, but was more consistently found in persons with AS. Lipid moiety in relation to protein moiety of VLDL and the ratio of total cholesterol in VLDL to serum triglycerides tended to be higher in ELp positive sera than ELp negative ones. ELp was found mainly in the density between 1.050 and 1.070g/ml and showed abnormally faster immunoelectrophoretic mobility than usual β-lipoprotein. The SDS disc gel electrophoretic pattern of the apoprotein of the subfraction (1.050<d<1.070) of ELp (+) serum was different from that of ELp (-) serum. Close association that we found between the high frequency of the ELp appearance and coronary heart disease does not prove any causal relationship, but suggests that even slight changes in serum lipid and lipoprotein patterns might be related to atherogenicity." @default.
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- W1433184109 date "1978-01-01" @default.
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- W1433184109 title "Studies on Serum Lipid and Lipoprotein Patterns in Patients with Coronary Heart Disease in Japanese" @default.
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- W1433184109 doi "https://doi.org/10.5551/jat1973.6.3_345" @default.
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