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- W1433370407 abstract "Basic helix-loop-helix (bHLH) transcription factors are known to play important roles in neuronal determination and differentiation. However, their exact roles in neural development still remain to be determined because of the functional redundancy. Here, we examined the roles of neural bHLH genes <i>Mash1</i> and <i>Math3</i> in the development of trigeminal and facial branchiomotor neurons, which derive from rhombomeres 2-4. In <i>Math3</i>-null mutant mice, facial branchiomotor neurons are misspecified, and both trigeminal and facial branchiomotor neurons adopt abnormal migratory pathways. In <i>Mash1;Math3</i> double-mutant mice, trigeminal and facial branchiomotor neurons are severely reduced in number partly because of increased apoptosis. In addition, neurons with migratory defects are intermingled over the midline from either side of the neural tube. Furthermore, oligodendrocyte progenitors of rhombomere 4 are reduced in number. In the absence of <i>Mash1</i> and <i>Math3</i>, expression of Notch signaling components is severely downregulated in rhombomere 4 and neural progenitors are not properly maintained, which may lead to intermingling of neurons and a decrease in oligodendrocyte progenitors. These results indicate that <i>Mash1</i> and <i>Math3</i> not only promote branchiomotor neuron development but also regulate the subsequent oligodendrocyte development and the cytoarchitecture by maintaining neural progenitors through Notch signaling." @default.
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- W1433370407 date "1997-02-08" @default.
- W1433370407 modified "2023-09-25" @default.
- W1433370407 title "Registering a fetus papyraceus" @default.
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- W1433370407 doi "https://doi.org/10.1136/bmj.314.7078.441a" @default.
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