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• W143343688 abstract "Research Article15 September 1995free access dad-1, an endogenous programmed cell death suppressor in Caenorhabditis elegans and vertebrates. A. Sugimoto A. Sugimoto Department of Biochemistry, University of Wisconsin-Madison 53706, USA. Search for more papers by this author R. R. Hozak R. R. Hozak Department of Biochemistry, University of Wisconsin-Madison 53706, USA. Search for more papers by this author T. Nakashima T. Nakashima Department of Biochemistry, University of Wisconsin-Madison 53706, USA. Search for more papers by this author T. Nishimoto T. Nishimoto Department of Biochemistry, University of Wisconsin-Madison 53706, USA. Search for more papers by this author J. H. Rothman J. H. Rothman Department of Biochemistry, University of Wisconsin-Madison 53706, USA. Search for more papers by this author A. Sugimoto A. Sugimoto Department of Biochemistry, University of Wisconsin-Madison 53706, USA. Search for more papers by this author R. R. Hozak R. R. Hozak Department of Biochemistry, University of Wisconsin-Madison 53706, USA. Search for more papers by this author T. Nakashima T. Nakashima Department of Biochemistry, University of Wisconsin-Madison 53706, USA. Search for more papers by this author T. Nishimoto T. Nishimoto Department of Biochemistry, University of Wisconsin-Madison 53706, USA. Search for more papers by this author J. H. Rothman J. H. Rothman Department of Biochemistry, University of Wisconsin-Madison 53706, USA. Search for more papers by this author Author Information A. Sugimoto1, R. R. Hozak1, T. Nakashima1, T. Nishimoto1 and J. H. Rothman1 1Department of Biochemistry, University of Wisconsin-Madison 53706, USA. The EMBO Journal (1995)14:4434-4441https://doi.org/10.1002/j.1460-2075.1995.tb00122.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Programmed cell death (apoptosis) is a normally occurring process used to eliminate unnecessary or potentially harmful cells in multicellular organisms. Recent studies demonstrate that the molecular control of this process is conserved phylogenetically in animals. The dad-1 gene, which encodes a novel 113 amino acid protein, was originally identified in a mutant hamster cell line (tsBN7) that undergoes apoptosis at restrictive temperature. We have identified a dad-1 homologue in Caenorhabditis elegans (Ce-dad-1) whose predicted product is > 60% identical to vertebrate DAD-1. A search of the sequence databases indicated that DAD-1-like proteins are also expressed in two plant species. Expression of either human dad-1 or Ce-dad-1 under control of a C.elegans heat-shock-inducible promoter resulted in a reduction in the number of programmed cell death corpses visible in C.elegans embryos. Extra surviving cells were present in these animals, indicating that both the human and C.elegans dad-1 genes can suppress developmentally programmed cell death. Ce-dad-1 was found to rescue mutant tsBN7 hamster cells from apoptotic death as efficiently as the vertebrate genes. These results suggest that dad-1, which is necessary for cell survival in a mammalian cell line, is sufficient to suppress some programmed cell death in C.elegans. Previous ArticleNext Article Volume 14Issue 181 September 1995In this issue RelatedDetailsLoading ..." @default.
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• W143343688 title "dad-1, an endogenous programmed cell death suppressor in Caenorhabditis elegans and vertebrates." @default.
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• W143343688 doi "https://doi.org/10.1002/j.1460-2075.1995.tb00122.x" @default.
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