Matches in SemOpenAlex for { <https://semopenalex.org/work/W143347545> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W143347545 endingPage "105.36" @default.
- W143347545 startingPage "105.36" @default.
- W143347545 abstract "Abstract Respiratory tract infections (RTIs) with influenza virus are a major global health concern, and together with secondary bacterial infections can cause fatal pneumonia. As B cells contribute to protection through the production of antibodies (Abs), we investigated how concomitant viral-bacterial super-infections alter the generation and maintenance of protective B cell responses in RTIs. We established two models of co-infections with influenza A virus (IAV) and Streptococcus pneumoniae (Sp). The first reflects individuals with a viral RTI that go on to contract a subsequent bacterial infection; the second considers individuals that are asymptomatic carriers of bacteria prior to contracting a viral RTI. Mice infected with Sp following IAV exhibit increased signs of morbidity, whereas mice carrying Sp prior to IAV exhibit less morbidity. Super-infection with Sp following -but not prior to- IAV significantly increases anti-viral serum Abs. Furthermore, the kinetics of the germinal center response and the ASC response in the lung-draining mediastinal lymph node and in the lungs are altered. We demonstrate that anti-viral Ab-specificities and -isotypes are differentially affected. Interestingly, the Ab response to Sp is not impacted in either scenario, suggesting distinct regulatory mechanisms for anti-viral and -bacterial B cell responses in these co-infection models." @default.
- W143347545 created "2016-06-24" @default.
- W143347545 creator A5005335205 @default.
- W143347545 creator A5024159764 @default.
- W143347545 creator A5027582796 @default.
- W143347545 creator A5048644594 @default.
- W143347545 creator A5058321884 @default.
- W143347545 creator A5066405485 @default.
- W143347545 creator A5082226526 @default.
- W143347545 date "2012-05-01" @default.
- W143347545 modified "2023-09-23" @default.
- W143347545 title "Modulation of Anti-Viral and Anti-Bacterial B Cell Responses in Super-infections (105.36)" @default.
- W143347545 doi "https://doi.org/10.4049/jimmunol.188.supp.105.36" @default.
- W143347545 hasPublicationYear "2012" @default.
- W143347545 type Work @default.
- W143347545 sameAs 143347545 @default.
- W143347545 citedByCount "0" @default.
- W143347545 crossrefType "journal-article" @default.
- W143347545 hasAuthorship W143347545A5005335205 @default.
- W143347545 hasAuthorship W143347545A5024159764 @default.
- W143347545 hasAuthorship W143347545A5027582796 @default.
- W143347545 hasAuthorship W143347545A5048644594 @default.
- W143347545 hasAuthorship W143347545A5058321884 @default.
- W143347545 hasAuthorship W143347545A5066405485 @default.
- W143347545 hasAuthorship W143347545A5082226526 @default.
- W143347545 hasConcept C126322002 @default.
- W143347545 hasConcept C142724271 @default.
- W143347545 hasConcept C159047783 @default.
- W143347545 hasConcept C159654299 @default.
- W143347545 hasConcept C203014093 @default.
- W143347545 hasConcept C2522874641 @default.
- W143347545 hasConcept C2776345407 @default.
- W143347545 hasConcept C2777546802 @default.
- W143347545 hasConcept C2777914695 @default.
- W143347545 hasConcept C2778158872 @default.
- W143347545 hasConcept C2778453870 @default.
- W143347545 hasConcept C2779134260 @default.
- W143347545 hasConcept C2781253189 @default.
- W143347545 hasConcept C3008058167 @default.
- W143347545 hasConcept C501593827 @default.
- W143347545 hasConcept C524204448 @default.
- W143347545 hasConcept C71924100 @default.
- W143347545 hasConcept C86803240 @default.
- W143347545 hasConcept C89423630 @default.
- W143347545 hasConcept C96926380 @default.
- W143347545 hasConceptScore W143347545C126322002 @default.
- W143347545 hasConceptScore W143347545C142724271 @default.
- W143347545 hasConceptScore W143347545C159047783 @default.
- W143347545 hasConceptScore W143347545C159654299 @default.
- W143347545 hasConceptScore W143347545C203014093 @default.
- W143347545 hasConceptScore W143347545C2522874641 @default.
- W143347545 hasConceptScore W143347545C2776345407 @default.
- W143347545 hasConceptScore W143347545C2777546802 @default.
- W143347545 hasConceptScore W143347545C2777914695 @default.
- W143347545 hasConceptScore W143347545C2778158872 @default.
- W143347545 hasConceptScore W143347545C2778453870 @default.
- W143347545 hasConceptScore W143347545C2779134260 @default.
- W143347545 hasConceptScore W143347545C2781253189 @default.
- W143347545 hasConceptScore W143347545C3008058167 @default.
- W143347545 hasConceptScore W143347545C501593827 @default.
- W143347545 hasConceptScore W143347545C524204448 @default.
- W143347545 hasConceptScore W143347545C71924100 @default.
- W143347545 hasConceptScore W143347545C86803240 @default.
- W143347545 hasConceptScore W143347545C89423630 @default.
- W143347545 hasConceptScore W143347545C96926380 @default.
- W143347545 hasIssue "1_Supplement" @default.
- W143347545 hasLocation W1433475451 @default.
- W143347545 hasOpenAccess W143347545 @default.
- W143347545 hasPrimaryLocation W1433475451 @default.
- W143347545 hasRelatedWork W1908431093 @default.
- W143347545 hasRelatedWork W2029912468 @default.
- W143347545 hasRelatedWork W2116498531 @default.
- W143347545 hasRelatedWork W2285301511 @default.
- W143347545 hasRelatedWork W2329957635 @default.
- W143347545 hasRelatedWork W2560654089 @default.
- W143347545 hasRelatedWork W3080787430 @default.
- W143347545 hasRelatedWork W4205474543 @default.
- W143347545 hasRelatedWork W4238085365 @default.
- W143347545 hasRelatedWork W4366422420 @default.
- W143347545 hasVolume "188" @default.
- W143347545 isParatext "false" @default.
- W143347545 isRetracted "false" @default.
- W143347545 magId "143347545" @default.
- W143347545 workType "article" @default.