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- W143348411 abstract "36Cl− efflux was studied in the isolated rat lens under two conditions that are known to decrease internal pH. The first follows exposure to a pulse of ammonium chloride (50 mm) and the second accompanies exposure to an acidified propionate (20 mm) solution. Under acidifying conditions, a stimulation in 36Cl efflux was observed, that was abolished on removing external Na+ and also on removing external Cl− and HCO3−. In the absence of external Cl−, the presence of HCO3− (16 mm) resulted in an increase in 36Cl efflux during internal acidification. In the absence of internal acidification, the addition of 0·1 mm dibutyrylcAMP or 0·5 mm IBMX to the external medium produced a rapid increase in 36Cl− efflux. This stimulation was reduced by 0·2 mm SITS. Neither cAMP or IBMX had any significant effect on the electrical resistance of the lens membranes. It is suggested that a coupled SITS-sensitive, Na+Cl−H−HCO3− exchange mechanism is activated when the lens internal pH falls and further that cAMP may play a role in regulating this mechanism." @default.
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- W143348411 date "1992-06-01" @default.
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- W143348411 title "Evidence for a exchange system in the mammalian lens" @default.
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- W143348411 doi "https://doi.org/10.1016/0014-4835(92)90158-o" @default.
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