Matches in SemOpenAlex for { <https://semopenalex.org/work/W143359528> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W143359528 endingPage "692" @default.
- W143359528 startingPage "679" @default.
- W143359528 abstract "Short episodes of ischemia and reperfusion in various organs may protect the organ itself, and the heart both as an immediate and a delayed effect. The present study investigates whether a systemic protection of vascular function occurs during adaption to ischemia. Brain ischemia was induced by bilateral ligation of the internal carotid arteries in C57BL6 mice, and 24-36 hours later rings of the thoracic aorta were mounted to study in vitro relaxation and contraction, or proteins were extracted for immunoblotting for endothelial nitric oxide synthase (eNOS) or inducible NOS (iNOS). eNOS decreased, while iNOS increased in the aortic wall after carotid artery ligation. In vitro contraction to increasing concentrations of prostaglandin F(2alpha) (PGF(2alpha)) was attenuated, while relaxation to acetylcholine (ACh) was enhanced. The latter was abolished by the iNOS-inhibitor aminoguanidine. When brain ischemia was induced in iNOS deficient mice, an increase of aortic eNOS was found 24 hours later. The ischemia-induced attenuated relaxation to PGF(2alpha) and enhanced relaxation to ACh were abolished. Aortic rings from mice with severe atherosclerosis (apolipoprotein E and low density lipoprotein receptor double knockout (ApoE/LDLr KO) mice) and spontaneous ischemic events in the heart or brain in vivo were also studied. Spontaneous ischemic events in ApoE/LDLr KO animals did not influence iNOS and eNOS in the vessel wall. A reduced contraction to PGF(2alpha) was observed, but relaxation to ACh was unchanged. These findings suggest that induced brain ischemia as a model of delayed, remote preconditioning protects vessel reactivity, and this protection is mediated by iNOS." @default.
- W143359528 created "2016-06-24" @default.
- W143359528 creator A5035158843 @default.
- W143359528 creator A5050380848 @default.
- W143359528 creator A5054709496 @default.
- W143359528 creator A5078460461 @default.
- W143359528 creator A5085379971 @default.
- W143359528 date "2002-06-01" @default.
- W143359528 modified "2023-09-27" @default.
- W143359528 title "Effects of spontaneous or induced brain ischemia on vessel reactivity" @default.
- W143359528 cites W1915460326 @default.
- W143359528 cites W1979295479 @default.
- W143359528 cites W1987259131 @default.
- W143359528 cites W1987293815 @default.
- W143359528 cites W1987405512 @default.
- W143359528 cites W1991615080 @default.
- W143359528 cites W1997370446 @default.
- W143359528 cites W2002303524 @default.
- W143359528 cites W2048543877 @default.
- W143359528 cites W2054025430 @default.
- W143359528 cites W2058520514 @default.
- W143359528 cites W2073682731 @default.
- W143359528 cites W2086636212 @default.
- W143359528 cites W2101247118 @default.
- W143359528 cites W2112656429 @default.
- W143359528 cites W2112850450 @default.
- W143359528 cites W2129117422 @default.
- W143359528 cites W2136078327 @default.
- W143359528 cites W2146350062 @default.
- W143359528 cites W2166859291 @default.
- W143359528 doi "https://doi.org/10.1016/s0024-3205(02)01711-3" @default.
- W143359528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12072156" @default.
- W143359528 hasPublicationYear "2002" @default.
- W143359528 type Work @default.
- W143359528 sameAs 143359528 @default.
- W143359528 citedByCount "20" @default.
- W143359528 countsByYear W1433595282013 @default.
- W143359528 countsByYear W1433595282014 @default.
- W143359528 countsByYear W1433595282015 @default.
- W143359528 countsByYear W1433595282017 @default.
- W143359528 countsByYear W1433595282019 @default.
- W143359528 crossrefType "journal-article" @default.
- W143359528 hasAuthorship W143359528A5035158843 @default.
- W143359528 hasAuthorship W143359528A5050380848 @default.
- W143359528 hasAuthorship W143359528A5054709496 @default.
- W143359528 hasAuthorship W143359528A5078460461 @default.
- W143359528 hasAuthorship W143359528A5085379971 @default.
- W143359528 hasConcept C120770815 @default.
- W143359528 hasConcept C126322002 @default.
- W143359528 hasConcept C134018914 @default.
- W143359528 hasConcept C163415756 @default.
- W143359528 hasConcept C179437574 @default.
- W143359528 hasConcept C185592680 @default.
- W143359528 hasConcept C2775910092 @default.
- W143359528 hasConcept C2777622882 @default.
- W143359528 hasConcept C2778326061 @default.
- W143359528 hasConcept C2779980429 @default.
- W143359528 hasConcept C519581460 @default.
- W143359528 hasConcept C541997718 @default.
- W143359528 hasConcept C71924100 @default.
- W143359528 hasConceptScore W143359528C120770815 @default.
- W143359528 hasConceptScore W143359528C126322002 @default.
- W143359528 hasConceptScore W143359528C134018914 @default.
- W143359528 hasConceptScore W143359528C163415756 @default.
- W143359528 hasConceptScore W143359528C179437574 @default.
- W143359528 hasConceptScore W143359528C185592680 @default.
- W143359528 hasConceptScore W143359528C2775910092 @default.
- W143359528 hasConceptScore W143359528C2777622882 @default.
- W143359528 hasConceptScore W143359528C2778326061 @default.
- W143359528 hasConceptScore W143359528C2779980429 @default.
- W143359528 hasConceptScore W143359528C519581460 @default.
- W143359528 hasConceptScore W143359528C541997718 @default.
- W143359528 hasConceptScore W143359528C71924100 @default.
- W143359528 hasIssue "6" @default.
- W143359528 hasLocation W1433595281 @default.
- W143359528 hasLocation W1433595282 @default.
- W143359528 hasOpenAccess W143359528 @default.
- W143359528 hasPrimaryLocation W1433595281 @default.
- W143359528 hasRelatedWork W1993142192 @default.
- W143359528 hasRelatedWork W2008087125 @default.
- W143359528 hasRelatedWork W2021947224 @default.
- W143359528 hasRelatedWork W2074932667 @default.
- W143359528 hasRelatedWork W2075290087 @default.
- W143359528 hasRelatedWork W2089295326 @default.
- W143359528 hasRelatedWork W2099366831 @default.
- W143359528 hasRelatedWork W2107563524 @default.
- W143359528 hasRelatedWork W2329991420 @default.
- W143359528 hasRelatedWork W2748952813 @default.
- W143359528 hasVolume "71" @default.
- W143359528 isParatext "false" @default.
- W143359528 isRetracted "false" @default.
- W143359528 magId "143359528" @default.
- W143359528 workType "article" @default.