FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W143368141> ?p ?o ?g. }

• W143368141 endingPage "225" @default.
• W143368141 startingPage "218" @default.
• W143368141 abstract "Although peripheral blood B-CLL cells are arrested in G0 phase of the cell cycle, a proliferating pool of cells in proliferation centers might be involved in disease progression. We have previously described an in vitro model of this proliferating pool of cells using B-CLL cells stimulated with immunostimulatory oligonucleotides (CpG-ODN) and interleukin-2. Lactacystin is a specific inhibitor of the proteasome and is a potent apoptosis inductor in resting peripheral B-CLL cells. In the present study, we investigated the effect of proteasome inhibition in proliferating B-CLL cells.The effect of proteasome inhibition was analyzed using thymidine incorporation, annexin V assays, and TUNEL staining. Immunoblots were performed to evaluate expression of proteins involved in cell cycle and apoptosis regulation.Lactacystin blocked cell cycle progression in activated B-CLL cells and inhibited degradation of p27. Upregulation of cyclin D2 and D3 in activated B-CLL cells was inhibited while the expression of cdk2, cdk4, and cyclin E remained unchanged. Activated B-CLL cells were more susceptible to apoptosis induction as compared to resting B-CLL cells. Apoptosis induction was accompanied by cleavage of Bax, procaspase 8, procaspase 9, and procaspase 3. However, a broad-spectrum caspase inhibitor (z-VAD.fmk) only partially inhibited cell death although DNA degradation was completely inhibited.Proteasome inhibition is highly effective in proliferating B-CLL cells and induces apoptosis using a caspase-dependent and -independent pathway." @default.
• W143368141 created "2016-06-24" @default.
• W143368141 creator A5005474411 @default.
• W143368141 creator A5022268863 @default.
• W143368141 creator A5029656956 @default.
• W143368141 creator A5039868942 @default.
• W143368141 creator A5062661095 @default.
• W143368141 creator A5066200247 @default.
• W143368141 date "2003-03-01" @default.
• W143368141 modified "2023-10-12" @default.
• W143368141 title "Cycling B-CLL cells are highly susceptible to inhibition of the proteasome" @default.
• W143368141 cites W122353466 @default.
• W143368141 cites W1536449496 @default.
• W143368141 cites W1568808961 @default.
• W143368141 cites W180295822 @default.
• W143368141 cites W1956007715 @default.
• W143368141 cites W1969617808 @default.
• W143368141 cites W1970001436 @default.
• W143368141 cites W1974796270 @default.
• W143368141 cites W1984591100 @default.
• W143368141 cites W2016133409 @default.
• W143368141 cites W2022736043 @default.
• W143368141 cites W2023611132 @default.
• W143368141 cites W2024846074 @default.
• W143368141 cites W2026216171 @default.
• W143368141 cites W2029959408 @default.
• W143368141 cites W2040202840 @default.
• W143368141 cites W2049435289 @default.
• W143368141 cites W2054449653 @default.
• W143368141 cites W2054473882 @default.
• W143368141 cites W2057292793 @default.
• W143368141 cites W2069132262 @default.
• W143368141 cites W2072088194 @default.
• W143368141 cites W2077754831 @default.
• W143368141 cites W2078161165 @default.
• W143368141 cites W2081315459 @default.
• W143368141 cites W2091403769 @default.
• W143368141 cites W2102585554 @default.
• W143368141 cites W2116382475 @default.
• W143368141 cites W2117184453 @default.
• W143368141 cites W2123781000 @default.
• W143368141 cites W2130361718 @default.
• W143368141 cites W2134791874 @default.
• W143368141 cites W2139410513 @default.
• W143368141 cites W2150267414 @default.
• W143368141 cites W2321522269 @default.
• W143368141 cites W2334494954 @default.
• W143368141 cites W2335735158 @default.
• W143368141 cites W2343131342 @default.
• W143368141 cites W2475150687 @default.
• W143368141 cites W26559748 @default.
• W143368141 cites W4241741898 @default.
• W143368141 cites W4251555887 @default.
• W143368141 cites W51210568 @default.
• W143368141 cites W6731686 @default.
• W143368141 doi "https://doi.org/10.1016/s0301-472x(02)01076-7" @default.
• W143368141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12644019" @default.
• W143368141 hasPublicationYear "2003" @default.
• W143368141 type Work @default.
• W143368141 sameAs 143368141 @default.
• W143368141 citedByCount "28" @default.
• W143368141 countsByYear W1433681412013 @default.
• W143368141 countsByYear W1433681412014 @default.
• W143368141 countsByYear W1433681412015 @default.
• W143368141 crossrefType "journal-article" @default.
• W143368141 hasAuthorship W143368141A5005474411 @default.
• W143368141 hasAuthorship W143368141A5022268863 @default.
• W143368141 hasAuthorship W143368141A5029656956 @default.
• W143368141 hasAuthorship W143368141A5039868942 @default.
• W143368141 hasAuthorship W143368141A5062661095 @default.
• W143368141 hasAuthorship W143368141A5066200247 @default.
• W143368141 hasBestOaLocation W1433681411 @default.
• W143368141 hasConcept C153911025 @default.
• W143368141 hasConcept C16438837 @default.
• W143368141 hasConcept C190283241 @default.
• W143368141 hasConcept C199835354 @default.
• W143368141 hasConcept C27740335 @default.
• W143368141 hasConcept C2776148510 @default.
• W143368141 hasConcept C2778367456 @default.
• W143368141 hasConcept C29537977 @default.
• W143368141 hasConcept C502942594 @default.
• W143368141 hasConcept C55493867 @default.
• W143368141 hasConcept C86803240 @default.
• W143368141 hasConcept C88634738 @default.
• W143368141 hasConcept C95444343 @default.
• W143368141 hasConceptScore W143368141C153911025 @default.
• W143368141 hasConceptScore W143368141C16438837 @default.
• W143368141 hasConceptScore W143368141C190283241 @default.
• W143368141 hasConceptScore W143368141C199835354 @default.
• W143368141 hasConceptScore W143368141C27740335 @default.
• W143368141 hasConceptScore W143368141C2776148510 @default.
• W143368141 hasConceptScore W143368141C2778367456 @default.
• W143368141 hasConceptScore W143368141C29537977 @default.
• W143368141 hasConceptScore W143368141C502942594 @default.
• W143368141 hasConceptScore W143368141C55493867 @default.
• W143368141 hasConceptScore W143368141C86803240 @default.
• W143368141 hasConceptScore W143368141C88634738 @default.
• W143368141 hasConceptScore W143368141C95444343 @default.

• next