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- W1433768935 abstract "The transcription factor Nrf2 regulates the expression of a large network of cytoprotective and metabolic enzymes and proteins. Compounds that directly and reversibly inhibit the interaction between Nrf2 and its main negative regulator Keap1 are potential pharmacological agents for a range of disease types including neurodegenerative conditions and cancer. We describe the development of a series of 1,4-diphenyl-1,2,3-triazole compounds that inhibit the Nrf2-Keap1 protein-protein interaction (PPI) in vitro and in live cells and up-regulate the expression of Nrf2-dependent gene products." @default.
- W1433768935 created "2016-06-24" @default.
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- W1433768935 date "2015-09-14" @default.
- W1433768935 modified "2023-10-18" @default.
- W1433768935 title "Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1–Nrf2 Protein–Protein Interaction" @default.
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- W1433768935 doi "https://doi.org/10.1021/acs.jmedchem.5b00602" @default.
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