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- W143396214 abstract "often referred to a specialized clinic to isolate the factors contributing to the disease and to tailor the therapy. While the general heart failure therapy does not differ between different etiologies, certain patients with DCM improve, others remain clinically stable for many years, while some deteriorate and require assist device or heart transplantation [3,4]. Most remarkably, some of the hearts undergo reverse remodeling to resume a normal geometry and function. Therefore, the ability to appreciate individual prognosis has manifold personal and clinical implications. The primary cause of myocardial injury may be either persistent or transient. The development of cardiomyopathy requires the coexistence of d ilated cardiomyopathy is a primary disease of the myocardium defined by the presence of left ventricular dilatation and left ventricular systolic dysfunction in the absence of abnormal loading conditions (hypertension, valve disease), or coronary artery disease sufficient to cause global systolic impairment [1]. The term “idiopathic” assumes ruling out identifiable and potentially treatable causes such as hypoor hyperthyroidism, tachyarrhythmia, alcohol abuse, dietary deficiency, or association with a systemic illness. Once a single mechanism to explain cardiomyopathy cannot be established, the condition can be described as “idiopathic.” In real live, extensive clinical investigation combined with endomyocardial biopsy failed to identify the specific cause of cardiomyopathy in 50% of patients referred to the Heart Failure Clinic [2]. In our opinion, DCM1, with the possible exception of familial cardiomyopathy, is a multifactorial disorder constituting a final common pathway of several injury mechanisms. These mechanisms often coexist to either initiate or aggravate the disease process. This complex etiology led to a simplified approach used in everyday clinical practice to classify cardiomyopathy with reduced ventricular function as either ischemic or non-ischemic. Patients with non-ischemic cardiomyopathy are" @default.
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- W143396214 date "2012-11-01" @default.
- W143396214 modified "2023-09-23" @default.
- W143396214 title "Predicting prognosis in dilated cardiomyopathy." @default.
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