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• W1434605413 abstract "To engineer constructs of the periodontal ligament (PDL), human PDL cells were incorporated into a matrix of hyaluronan, gelatin, and type I collagen (COLI) in sample holders (13×1 mm) of six-well Biopress culture plates. The loading dynamics of the PDL were mimicked by applying a cyclic compressive strain of 33.4 kPa (340.6 gm/cm2) to the constructs for 1.0 s every 60 s, for 6, 12, and 24 h in a Flexercell FX-4000C Strain Unit. Compression significantly increased the number of nonviable cells and increased the expression of several apoptosis-related genes, including initiator and executioner caspases. Of the 15 extracellular matrix genes screened, most were upregulated at some point after 6–12 h deformation, but all were downregulated at 24 h, except for MMPs1–3 and CTGF. In culture supernatants, matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinases-1 (TIMP-1) protein levels were upregulated at 24 h; receptor activator of nuclear kappa factor B (RANKL), osteoprotegerin (OPG) and fibroblast growth factor-2 (FGF-2) were unchanged; and connective tissue growth factor (CTGF) not detected. The low modulus of elasticity of the constructs was a disadvantage—future mechanobiology studies and tissue engineering applications will require constructs with much higher stiffness. Since the major structural protein of the PDL is COLI, a more rational approach would be to permeabilize preformed COLI scaffolds with PDL-populated matrices." @default.
• W1434605413 created "2016-06-24" @default.
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• W1434605413 date "2015-02-01" @default.
• W1434605413 modified "2023-09-26" @default.
• W1434605413 title "Engineering the Periodontal Ligament in Hyaluronan–Gelatin–Type I Collagen Constructs: Upregulation of Apoptosis and Alterations in Gene Expression by Cyclic Compressive Strain" @default.
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• W1434605413 doi "https://doi.org/10.1089/ten.tea.2014.0221" @default.
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