FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W143478110> ?p ?o ?g. }

• W143478110 abstract "Background: Previous reports have demonstrated the association between single nucleotide polymorphism (SNP) of the eNOS gene and atrial fibrillation (AF). This study evaluated whether eNOS gene variants are associated with high-sensitivity C-reactive protein (hsCRP) and AF recurrence after radiofrequency catheter ablation (RFCA).Methods: A total of 500 consecutive patients (56±11 years, 77% male) with paroxysmal (68%) or persistent (32%) AF who underwent RFCA were included. Plasma hsCRP concentration was measured and SNP of the eNOS gene, rs1799983, was genotyped. A 24- to 48-hour Holter ECG recording was performed at 3, 6, and 12 months after the ablation.Results: When we compared the patients with rs1799983 variant allele (T, n=84) and those without T allele (n=416), rs1799983 variant allele carriers are more likely to have coronary artery disease or stroke (31.0% vs. 17.8%, p=0.004). The early recurrence (ER) of AF (within 3 months) was observed in 31.8%, whereas the clinical recurrence (CR) of AF (after 3 months) occurred in 24.8% of the patients during the median 17 months of follow-up. The patients with ER were more likely to have persistent AF (44.4% vs. 27.1%, p<0.001) and larger left atrium (42.8±6.4 vs. 41.2±6.2 mm, p=0.011) than those without the ER. Although rs1799983 variant was not associated with the CR, carriers of the variant allele had an increased risk of the ER (OR 1.717 for TT+GT vs. GG, 95% CI 1.059-2.785, p=0.028) and experienced recurrence earlier than those without variant allele (11±16 vs. 20±25 days, p=0.016). However, there were no significant differences in hsCRP between variant and non-variant patients (2.32±4.94 vs. 2.06±4.36 mg/L, p=0.618). A multiple logistic regression analysis showed that the rs1799983 variant (OR 1.714, 95% CI 1.045-2.812, p=0.033) and persistent AF (OR 1.905, 95% CI 1.234-2.939, p=0.004) were independent predictors of the ER.Conclusions: The rs1799983 variant of the eNOS gene was associated with early recurrence after RFCA, but not with hsCRP level. A study that further investigates the relationship between genetic variations of eNOS and post-ablation inflammatory process will be warranted." @default.
• W143478110 created "2016-06-24" @default.
• W143478110 creator A5002263251 @default.
• W143478110 creator A5013435322 @default.
• W143478110 creator A5015102556 @default.
• W143478110 creator A5017792494 @default.
• W143478110 creator A5027765634 @default.
• W143478110 creator A5033022258 @default.
• W143478110 creator A5037435652 @default.
• W143478110 creator A5057554500 @default.
• W143478110 creator A5073912011 @default.
• W143478110 date "2012-11-20" @default.
• W143478110 modified "2023-09-24" @default.
• W143478110 title "Abstract 18508: The Association of eNOS Gene Single Nucleotide Polymorphism rs1799983 with High-Sensitivity C-Reactive Protein and Early Recurrence of Atrial Fibrillation after Radiofrequency Catheter Ablation" @default.
• W143478110 hasPublicationYear "2012" @default.
• W143478110 type Work @default.
• W143478110 sameAs 143478110 @default.
• W143478110 citedByCount "0" @default.
• W143478110 crossrefType "journal-article" @default.
• W143478110 hasAuthorship W143478110A5002263251 @default.
• W143478110 hasAuthorship W143478110A5013435322 @default.
• W143478110 hasAuthorship W143478110A5015102556 @default.
• W143478110 hasAuthorship W143478110A5017792494 @default.
• W143478110 hasAuthorship W143478110A5027765634 @default.
• W143478110 hasAuthorship W143478110A5033022258 @default.
• W143478110 hasAuthorship W143478110A5037435652 @default.
• W143478110 hasAuthorship W143478110A5057554500 @default.
• W143478110 hasAuthorship W143478110A5073912011 @default.
• W143478110 hasConcept C104317684 @default.
• W143478110 hasConcept C126322002 @default.
• W143478110 hasConcept C134018914 @default.
• W143478110 hasConcept C135763542 @default.
• W143478110 hasConcept C153209595 @default.
• W143478110 hasConcept C164705383 @default.
• W143478110 hasConcept C180754005 @default.
• W143478110 hasConcept C2776131983 @default.
• W143478110 hasConcept C2777622882 @default.
• W143478110 hasConcept C2778213512 @default.
• W143478110 hasConcept C2778326061 @default.
• W143478110 hasConcept C2779161974 @default.
• W143478110 hasConcept C519581460 @default.
• W143478110 hasConcept C54355233 @default.
• W143478110 hasConcept C71924100 @default.
• W143478110 hasConcept C86803240 @default.
• W143478110 hasConcept C90924648 @default.
• W143478110 hasConceptScore W143478110C104317684 @default.
• W143478110 hasConceptScore W143478110C126322002 @default.
• W143478110 hasConceptScore W143478110C134018914 @default.
• W143478110 hasConceptScore W143478110C135763542 @default.
• W143478110 hasConceptScore W143478110C153209595 @default.
• W143478110 hasConceptScore W143478110C164705383 @default.
• W143478110 hasConceptScore W143478110C180754005 @default.
• W143478110 hasConceptScore W143478110C2776131983 @default.
• W143478110 hasConceptScore W143478110C2777622882 @default.
• W143478110 hasConceptScore W143478110C2778213512 @default.
• W143478110 hasConceptScore W143478110C2778326061 @default.
• W143478110 hasConceptScore W143478110C2779161974 @default.
• W143478110 hasConceptScore W143478110C519581460 @default.
• W143478110 hasConceptScore W143478110C54355233 @default.
• W143478110 hasConceptScore W143478110C71924100 @default.
• W143478110 hasConceptScore W143478110C86803240 @default.
• W143478110 hasConceptScore W143478110C90924648 @default.
• W143478110 hasLocation W1434781101 @default.
• W143478110 hasOpenAccess W143478110 @default.
• W143478110 hasPrimaryLocation W1434781101 @default.
• W143478110 hasRelatedWork W1594258139 @default.
• W143478110 hasRelatedWork W1986010379 @default.
• W143478110 hasRelatedWork W1994378980 @default.
• W143478110 hasRelatedWork W2000423124 @default.
• W143478110 hasRelatedWork W2016145170 @default.
• W143478110 hasRelatedWork W2026844956 @default.
• W143478110 hasRelatedWork W2067808718 @default.
• W143478110 hasRelatedWork W2469229815 @default.
• W143478110 hasRelatedWork W2561785143 @default.
• W143478110 hasRelatedWork W2773756397 @default.
• W143478110 hasRelatedWork W2989031263 @default.
• W143478110 hasRelatedWork W2991407743 @default.
• W143478110 hasRelatedWork W2997332520 @default.
• W143478110 hasRelatedWork W3029824234 @default.
• W143478110 hasRelatedWork W3031479144 @default.
• W143478110 hasRelatedWork W3103374415 @default.
• W143478110 hasRelatedWork W3106964256 @default.
• W143478110 hasRelatedWork W3134412165 @default.
• W143478110 hasRelatedWork W3141133541 @default.
• W143478110 hasRelatedWork W2557426275 @default.
• W143478110 hasVolume "126" @default.
• W143478110 isParatext "false" @default.
• W143478110 isRetracted "false" @default.
• W143478110 magId "143478110" @default.
• W143478110 workType "article" @default.